The effect of correlated noise in a Gompertz tumor growth model

被引:15
|
作者
Behera, Anita [1 ]
Francesca, S. [2 ]
O'Rourke, C. [2 ]
机构
[1] Queens Univ Belfast, Sch Biomed Sci, Belfast BT9 7AB, Antrim, North Ireland
[2] Queens Univ Belfast, Sch Math & Phys, Belfast BT7 1NN, Antrim, North Ireland
关键词
fluctuation phenomena; random processes; noise; brownian motion;
D O I
10.1590/S0103-97332008000200011
中图分类号
O4 [物理学];
学科分类号
0702 ;
摘要
We study the effect of noise in an avascular tumor growth model. The growth mechanism we consider is the Gompertz model. The steady state probability distributions and average population of tumor cells are analyzed within the Fokker-Planck formalism to investigate the importance of additive and multiplicative noise. We consider the effect of correlation on tumor growth for both the case of nonzero and zero correlation time. It is observed that the Gompertz model, driven by correlated noise exhibits a stochastic resonance and phase transition. This behaviour is attributed to multiplicative noise. In the case of nonzero correlation time, it is found that the correlation strength and correlation time have opposite effects on the steady state probability distribution. The Gompertz model simulations are also shown to be in qualitative agreement with another similiar non-bistable system, the logistic model.
引用
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页码:272 / 278
页数:7
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