Longitudinal intellectual assessment of children with HIV infection

The objective of this paper was to describe the intellectual development of 39 children with HIV infection. The children received serial evaluations over a 10-year period. Thirty-nine children were assessed with age-appropriate intellectual measures at regular intervals as part of their treatment in the HIV Program of a children's hospital. Children showed an 24-point drop in mean Bayley Mental scores over the first 2 years of life. McCarthy scores remained in the low average range from ages 3-5 years. IQ scores were stable by age 6 in the low average range, and unchanged through age 12. Significant changes in memory, vocabulary, and performance subtests were noted. Children with HIV infection demonstrated a significant decline in mental functioning over the first 2 years of life, fell into the low average range by age 3, and remained in the low average range, with subtle changes in some areas.