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Univ Newcastle, Newcastle Mater Misericordiae Hosp, Dept Clin Pharmacol & Toxicol, Discipline Clin Pharmacol, Newcastle, NSW 2298, Australia Univ Newcastle, Newcastle Mater Misericordiae Hosp, Dept Clin Pharmacol & Toxicol, Discipline Clin Pharmacol, Newcastle, NSW 2298, Australia