Stem cells for Parkinson disease and ALS: replacement or protection?

被引:60
|
作者
Svendsen, CN [1 ]
Langston, JW
机构
[1] Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA
[2] Parkinsons Inst, Sunnyvale, CA 94089 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1038/nm0304-224
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Using stem cells to generate new neurons and replace those lost in diseases such as Parkinson and amyotrophic lateral sclerosis would be a major breakthrough, but significant hurdles remain before this goal can be realized. Instead, a more practical short-term approach may be to use stem cells to protect neurons dying in these diseases.
引用
收藏
页码:224 / 225
页数:2
相关论文
共 50 条
  • [31] Stem cells for cell therapy in Parkinson's disease
    Lindvall, O
    PHARMACOLOGICAL RESEARCH, 2003, 47 (04) : 279 - 287
  • [32] Mesenchymal stem cells and neuroregeneration in Parkinson's disease
    Glavaski-Joksimovic, Aleksandra
    Bohn, Martha C.
    EXPERIMENTAL NEUROLOGY, 2013, 247 : 25 - 38
  • [33] The promise and potential of stem cells in Parkinson’s disease
    Lauren Gravitz
    Nature, 2021, 597 (7878) : S8 - S10
  • [34] Potential Parkinson disease and ALS drug
    Pamela Feliciano
    Nature Genetics, 2012, 44 (11) : 1178 - 1178
  • [35] Neurorehabilitation of Parkinson's Disease and ALS
    Lou, Jau-Shin
    NEUROREHABILITATION, 2015, 37 (01) : 1 - 2
  • [36] Stem cells therapy for ALS
    Mazzini, Letizia
    Vescovi, Angelo
    Cantello, Roberto
    Gelati, Maurizio
    Vercelli, Alessandro
    EXPERT OPINION ON BIOLOGICAL THERAPY, 2016, 16 (02) : 187 - 199
  • [37] Stem cells and the ALS neurologist
    Maragakis, Nicholas J.
    AMYOTROPHIC LATERAL SCLEROSIS, 2010, 11 (05): : 417 - 423
  • [38] Endothelial progenitor cells: Cardiovascular protection in Parkinson's disease?
    Pezzoli, Gianni
    Cavanna, Ferruccio
    Cassani, Erica
    Barichella, Michela
    Pinelli, Giovanna
    Iorio, Laura
    Pusani, Chiara
    Canesi, Margherita
    Natuzzi, Francesca
    Cazzola, Roberta
    Cestaro, Benvenuto
    Cereda, Emanuele
    INTERNATIONAL JOURNAL OF CARDIOLOGY, 2015, 197 : 200 - 202
  • [39] The bioengineering of stem cells to create dopamine replacement neurons is not the solution for Parkinson's
    Carey, Robert J.
    Carey, Jack L.
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2017, 163 : 36 - 37
  • [40] Induced pluripotent stem cells from ALS patients for disease modeling
    Richard, Jean-Philippe
    Maragakis, Nicholas J.
    BRAIN RESEARCH, 2015, 1607 : 15 - 25