Impact of genomic polymorphism on arterial hypertension after aortic coarctation repair

被引:6
|
作者
Hager, Alfred [1 ]
Bildau, Judith [2 ]
Kreuder, Joachim [2 ]
Kaemmerer, Harald [1 ]
Hess, John [1 ]
机构
[1] Tech Univ Munich, Deutsch Herzzentrum Munchen, Dept Pediat Cardiol & Congenital Heart Dis, D-80636 Munich, Germany
[2] Univ Giessen, Dept Pediat Cardiol, D-35390 Giessen, Germany
关键词
Congenital heart disease; Coarctation of the aorta; Arterial hypertension; Genomic polymorphism; RECEPTOR GENE POLYMORPHISMS; AMBULATORY BLOOD-PRESSURE; LEFT-VENTRICULAR MASS; TERM ASSESSMENT COALA; OXIDE SYNTHASE GENE; ELASTIC PROPERTIES; I/D-POLYMORPHISM; SURGICAL REPAIR; ARCH GEOMETRY; ACE GENE;
D O I
10.1016/j.ijcard.2010.04.090
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: Even after repair of aortic coarctation without restenosis there is a high incidence of arterial hypertension. This study was performed to assess the contribution of several inherited gene polymorphisms, which are known to be related to essential hypertension. Patients and methods: 122 patients aged 17-72 years, 46 women, and 2-27 years after repair of isolated aortic coarctation without restenosis were investigated. Genomic polymorphism of angiotensin converting enzyme (ACE I/D), angiotensinogen (AGT, c.704C>T), angiotensin II receptor type 1 (AGTR1, c.1166A>C), aldosterone synthase (CYP11B2, c.-344C>T), endothelin 1 (EDN1, EDN1/ex5-c.5665G>T), G protein (GNB3, c.825C>T), G protein-coupled receptor kinase 4 (GRK4, c.679C>T), fibrillin 1 (FBN1, VNTR(TAAA)) and two polymorphisms each of the beta 1 adrenoreceptor (ADRB1, c.145G>A and c.1165C>G), beta 2 adrenoreceptor (ADRB2, c.46A>G and c.79C>G), and endothelial NO synthase (NOS3, intron 4 I/D and NOS3, c.894G>T) were determined by PCR amplification and fragment length analysis. Patients were classified "normotensive", if they were not on antihypertensive drugs and showed normal blood pressure both on ambulatory measurement and exercise test. Results: None of the investigated genomic polymorphism could be related to hypertension. Only patients with the ACE I/I genotype had a less pronounced nocturnal dipping and patients with a ADRB1 c.1165 C/C genotype had a higher systolic and mean blood pressure at night. Conclusions: Development of late hypertension after aortic coarctation repair could not be related to the investigated genomic polymorphism. The correlation of the ACE I/D and the ADRB1 c.1165C>G polymorphism to nocturnal dipping and blood pressure at nighttime needs further confirmation. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:63 / 68
页数:6
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