Congestive heart failure associated with itraconazole

被引：130
|
作者：
Ahmad, SR
Singer, SJ
Leissa, BG
机构：
[1] US FDA, Off Postmkt Drug Risk Assessment, Ctr Drug Evaluat & Res, Rockville, MD 20857 USA
[2] US FDA, Div Special Pathogen & Immunol Drug Prod, Ctr Drug Evaluat & Res, Rockville, MD 20857 USA
来源：
LANCET | 2001年 / 357卷 / 9270期
关键词：
D O I：
10.1016/S0140-6736(00)04891-1
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Itraconazole is a synthetic antifungal agent approved in the USA far the treatment of onychomycosis and serious systemic fungal infections. Animal and clinical pharmacology studies suggest negative inotropic effects with itraconazole. Data from the US Food and Drug Administration's Adverse Event Reporting System suggest that use of itraconazole is associated with congestive heart failure. We summarise the details of 58 cases suggestive of congestive heart failure in association with the use of itraconazole. Labelling of itraconazole has been changed to alert physicians to this new finding.
引用
收藏
页码：1766 / 1767
页数：2
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