Synthesis, characterization, and anticancer activity of dithiocarbamate ruthenium(II) complexes

被引：13
|
作者：
Dou, Ye-Hong [1 ]
Xu, Shou-De [1 ]
Chen, Yi [1 ]
Wu, Xiang-Hua [1 ]
机构：
[1] Yunnan Normal Univ, Chem & Pharmaceut Dept, Coll Chem & Chem Engn, Kunming 650500, Yunnan, Peoples R China
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2017年 / 192卷 / 11期
基金：
中国国家自然科学基金;
关键词：
Cyclopentadienyl; cytotoxic activity; dithiocarbamates; p-arene; ruthenium(II) complexes; IN-VITRO CYTOTOXICITY; BETA-KETOAMINE LIGANDS; ARENE COMPLEXES; ANTIPROLIFERATIVE ACTIVITY; GOLD(III) COMPLEXES; METAL-COMPLEXES; CANCER-CELLS; CHEMISTRY; DESIGN; AGENTS;
D O I：
10.1080/10426507.2017.1359594
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Twelve arene and cyclopentadienyl ruthenium(II) dithiocarbamate complexes have been prepared and characterized by spectroscopic methods. The structures of 3a and 3c have been determined by X-ray crystallography. Their in vitro antitumor activities were evaluated by MTT method against four tumor cells (SKOV-3, HepG-2, A549, as well as PC12) and two murine cells (RAW246.7 and L6). Notably, the results in vitro indicated that the arene ruthenium(II) complex 3e (N-methyl piperazine) displayed the highest activity and selectivity towards cancer HepG-2 cells.
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页码：1219 / 1223
页数：5
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