HPV vaccines: Translating immunogenicity into efficacy

被引：22

作者：

Turner, Taylor B. ^{[1
]}

Huh, Warner K. ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Obstet & Gynecol, Div Gynecol Oncol, Birmingham, AL 35294 USA

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2016年 / 12卷 / 06期

关键词：

Human papilloma virus vaccine; immune correlate; VIRUS-LIKE PARTICLES; HPV-16/18 AS04-ADJUVANTED VACCINE; FOLLOW-UP; SUSTAINED EFFICACY; CERVICAL-CANCER; PAPILLOMAVIRUS; ANTIBODIES; INFECTION; PROTECTION; POSTVACCINATION;

D O I：

10.1080/21645515.2015.1103936

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Currently available human papillomavirus (HPV) vaccines are very successful at preventing persistent HPV infection and premalignant cervical lesions. In part due to the unique aspects of HPV immunogenicity and high levels of efficacy no immune correlate has been identified for HPV vaccination. Serum neutralizing antibodies are used to measure vaccine response, but their role as a correlate has not been verified, and this theory fails to explain the prevention of HPV related non-mucosal lesions. Identifying a true correlate would aid in future work in this area but will be difficult in the setting of a highly efficacious vaccine.

引用

页码：1403 / 1405

页数：3

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