HPV vaccines: Translating immunogenicity into efficacy

被引：22
|
作者：
Turner, Taylor B. [1 ]
Huh, Warner K. [1 ]
机构：
[1] Univ Alabama Birmingham, Dept Obstet & Gynecol, Div Gynecol Oncol, Birmingham, AL 35294 USA
来源：
HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2016年 / 12卷 / 06期
关键词：
Human papilloma virus vaccine; immune correlate; VIRUS-LIKE PARTICLES; HPV-16/18 AS04-ADJUVANTED VACCINE; FOLLOW-UP; SUSTAINED EFFICACY; CERVICAL-CANCER; PAPILLOMAVIRUS; ANTIBODIES; INFECTION; PROTECTION; POSTVACCINATION;
D O I：
10.1080/21645515.2015.1103936
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Currently available human papillomavirus (HPV) vaccines are very successful at preventing persistent HPV infection and premalignant cervical lesions. In part due to the unique aspects of HPV immunogenicity and high levels of efficacy no immune correlate has been identified for HPV vaccination. Serum neutralizing antibodies are used to measure vaccine response, but their role as a correlate has not been verified, and this theory fails to explain the prevention of HPV related non-mucosal lesions. Identifying a true correlate would aid in future work in this area but will be difficult in the setting of a highly efficacious vaccine.
引用
收藏
页码：1403 / 1405
页数：3
相关论文
共 50 条
  • [1] Immunogenicity of HPV prophylactic vaccines: Serology assays and their use in HPV vaccine evaluation and development
    Pinto, Ligia A.
    Dillner, Joakim
    Beddows, Simon
    Unger, Elizabeth R.
    VACCINE, 2018, 36 (32) : 4792 - 4799
  • [2] Predictive Markers of Immunogenicity and Efficacy for Human Vaccines
    Van Tilbeurgh, Matthieu
    Lemdani, Katia
    Beignon, Anne-Sophie
    Chapon, Catherine
    Tchitchek, Nicolas
    Cheraitia, Lina
    Marcos Lopez, Ernesto
    Pascal, Quentin
    Le Grand, Roger
    Maisonnasse, Pauline
    Manet, Caroline
    VACCINES, 2021, 9 (06)
  • [3] EFFICACY AND IMMUNOGENICITY OF DNA VACCINES FOR VIRAL DISEASES
    LIU, MA
    ULMER, J
    SHIVER, J
    FRIEDMAN, A
    MCCLEMENTS, W
    DONNELLY, J
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1995, : 278 - 278
  • [4] Methods for improving the immunogenicity and efficacy of cancer vaccines
    Pilla, Lorenzo
    Ferrone, Soldano
    Maccalli, Cristina
    EXPERT OPINION ON BIOLOGICAL THERAPY, 2018, 18 (07) : 765 - 784
  • [5] Immunogenicity and Efficacy Evaluation of Subunit Astrovirus Vaccines
    Bidokhti, Mehdi R. M.
    Ullman, Karin
    Hammer, Anne Sofie
    Jensen, Trine Hammer
    Chriel, Mariann
    Byrareddy, Siddappa N.
    Baule, Claudia
    VACCINES, 2019, 7 (03)
  • [6] Immunogenicity, safety, and efficacy of the HPV vaccines among people living with HIV: A systematic review and meta-analysis
    Staadegaard, Lisa
    Ronn, Minttu M.
    Soni, Nirali
    Bellerose, Meghan E.
    Bloem, Paul
    Brisson, Marc
    Maheu-Giroux, Mathieu
    Barnabas, Ruanne, V
    Drolet, Melanie
    Mayaud, Philippe
    Dalal, Shona
    Boily, Marie-Claude
    ECLINICALMEDICINE, 2022, 52
  • [7] Immunogenicity, safety, and efficacy of the HPV vaccines among people living with HIV: A systematic review and meta-analysis
    Staadegaard, Lisa
    Ronn, Minttu M.
    Soni, Nirali
    Bellerose, Meghan E.
    Bloem, Paul
    Brisson, Marc
    Maheu-Giroux, Mathieu
    Barnabas, Ruanne., V
    Drolet, Melanie
    Mayaud, Philippe
    Dalal, Shona
    Boily, Marie-Claude
    ECLINICALMEDICINE, 2022, 52
  • [8] Immunogenicity and Efficacy of Personalized Adjuvant mRNA Cancer Vaccines
    Berraondo, Pedro
    Cuesta, Raquel
    Sanmamed, Miguel F.
    Melero, Ignacio
    CANCER DISCOVERY, 2024, 14 (11) : 2021 - 2024
  • [9] A SYSTEMATIC REVIEW OF THE EFFICACY, SAFETY AND IMMUNOGENICITY OF PLAGUE VACCINES
    Hartley, L.
    Harold, S.
    Hawe, E.
    VALUE IN HEALTH, 2022, 25 (07) : S607 - S608
  • [10] Update on Safety and Efficacy of HPV Vaccines: Focus on Gardasil
    Soliman, Monica
    Oredein, Ololade
    Dass, Crispin R.
    INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, 2021, 10 (02) : 101 - 112
12345