An improved bidentate complex of iridium as a catalyst for hydrogen isotope exchange

被引：17

作者：

Herbert, JM ^{[1
]}

Kohler, AD ^{[1
]}

McNeill, AH ^{[1
]}

机构：

[1] Sanofi Aventis, Isotope Chem & Metabolite Synth Dept, Alnwick NE66 2JH, Northd, England

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2005年 / 48卷 / 04期

关键词：

iridium complexes; deuterium exchange; isotope exchange;

D O I：

10.1002/jlcr.921

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Iridium(l) complexes 1, containing bidentate phosphines, and 3, with arsine ligands, are generated in situ. These species mediate hydrogen isotope exchange in a variety of aromatic substrates including benzyl ketones. Although the catalytic activities of complexes 1 and 3 are generally unexceptional, a logical step leads to the use of [ethylene-1,2-bis(diphenylarsine)](cyclooctadiene)iridium(I) tetrafluoroborate (5), which is an efficient catalyst for both aryl and benzyl ketones, and mediates exchange to a. substantial extent in other substrates also. Copyright (c) 2005 John Wiley & Sons, Ltd.

引用

页码：285 / 294

页数：10

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