DYNLL1 INHIBITS DNA END RESECTION IN BRCA1-DEFICIENT CELLS AND REGULATES PARP INHIBITOR SENSITIVITY

被引：0

作者：

He, Yizhou Joseph ^{[1
]}

Meghani, Khyati ^{[1
]}

Caron, Marie-Christine ^{[2
,3
]}

Yang, Chunyu ^{[1
]}

Ronato, Daryl A. ^{[2
,3
]}

Bian, Jie ^{[1
]}

Sharma, Anchal ^{[4
]}

Miller, Jessica ^{[1
]}

Joshi, Niraj ^{[1
]}

Detappe, Alexandre ^{[5
]}

Doench, John G. ^{[6
]}

Legube, Gaelle ^{[7
]}

Root, David E. ^{[6
]}

D'Andrea, Alan D. ^{[1
,8
]}

Drane, Pascal ^{[1
]}

De, Subhojyoti ^{[4
]}

Konstantinopoulos, Panagiotis ^{[5
]}

Masson, Jean-Yves ^{[2
,3
]}

Chowdhury, Dipanjan ^{[1
,6
,9
]}

机构：

[1] Harvard Med Sch, Dana Farber Canc Inst, Dept Radiat Oncol, Div Radiat & Genome Stabil, Boston, MA 02215 USA

[2] CHU Quebec Res Ctr, Genome Stabil Lab, Oncol Axis, HDQ Pavil,9 McMahon, Quebec City, PQ G1R 2J6, Canada

[3] Laval Univ, Canc Res Ctr, Dept Mol Biol Med Biochem & Pathol, Quebec City, PQ G1V 0A6, Canada

[4] Rutgers Canc Inst New Jersey, New Brunswick, NJ USA

[5] Harvard Med Sch, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA

[6] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[7] Univ Toulouse, CNRS, CBI, LBCMCP,UT3, 118 Route Narbonne, F-31062 Toulouse, France

[8] Harvard Med Sch, Dana Farber Canc Inst, Ctr DNA Damage & Repair, Boston, MA 02215 USA

[9] Harvard Med Sch, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

来源：

CLINICAL CANCER RESEARCH | 2019年 / 25卷 / 22期

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

GMM-027

引用

页码：90 / 90

页数：1

共 50 条

[31] Folliculin deficient renal cancer cells exhibit BRCA1 A complex expression impairment and sensitivity to PARP1 inhibitor olaparib
Zhang, Qi
Xu, Yingkun
Zhang, Zhiyu
Li, Jianyi
Xia, Qinghua
Chen, Yougen
GENE, 2021, 769
[32] Akt1 inhibits homologous recombination in Brca1-deficient cells by blocking the Chk1-Rad51 pathway
Y Jia
W Song
F Zhang
J Yan
Q Yang
Oncogene, 2013, 32 : 1943 - 1949
[33] PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer
Ding, Liya
Kim, Hye-Jung
Wang, Qiwei
Kearns, Michael
Jiang, Tao
Ohlson, Carolynn E.
Li, Ben B.
Xie, Shaozhen
Liu, Joyce F.
Stover, Elizabeth H.
Howitt, Brooke E.
Bronson, Roderick T.
Lazo, Suzan
Roberts, Thomas M.
Freeman, Gordon J.
Konstantinopoulos, Panagiotis A.
Matulonis, Ursula A.
Zhao, Jean J.
CELL REPORTS, 2018, 25 (11): : 2972 - +
[34] CTLA-4 Blockade Synergizes Therapeutically with PARP Inhibition in BRCA1-Deficient Ovarian Cancer
Higuchi, Tomoe
Flies, Dallas B.
Marjon, Nicole A.
Mantia-Smaldone, Gina
Ronner, Lukas
Gimotty, Phyllis A.
Adams, Sarah F.
CANCER IMMUNOLOGY RESEARCH, 2015, 3 (11) : 1257 - 1268
[35] The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity
Becker, Jordan R.
Cuella-Martin, Raquel
Barazas, Marco
Liu, Rui
Oliveira, Catarina
Oliver, Antony W.
Bilham, Kirstin
Holt, Abbey B.
Blackford, Andrew N.
Heierhorst, Jorg
Jonkers, Jos
Rottenberg, Sven
Chapman, J. Ross
NATURE COMMUNICATIONS, 2018, 9
[36] The Apoptotic Resistance of BRCA1-Deficient Ovarian Cancer Cells is Mediated by cAMP
Yue, Wei
Ma, Jihong
Xiao, Yinan
Wang, Pan
Gu, Xiaoyang
Xie, Bingteng
Li, Mo
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 10
[37] The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity
Jordan R. Becker
Raquel Cuella-Martin
Marco Barazas
Rui Liu
Catarina Oliveira
Antony W. Oliver
Kirstin Bilham
Abbey B. Holt
Andrew N. Blackford
Jörg Heierhorst
Jos Jonkers
Sven Rottenberg
J. Ross Chapman
Nature Communications, 9
[38] Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and BRCA1-deficient cells
Michelena, Jone
Pellegrino, Stefania
Spegg, Vincent
Altmeyer, Matthias
LIFE SCIENCE ALLIANCE, 2021, 4 (06)
[39] PTIP UFMylation promotes replication fork degradation in BRCA1-deficient cells
Tan, Qunsong
Xu, Xingzhi
JOURNAL OF BIOLOGICAL CHEMISTRY, 2024, 300 (06)
[40] TIPIN is essential for chromosome stability and cell viability in BRCA1-deficient cells
Abe, Takuya
Yoshimoto, Yui
Matsuno, Seiya
Yoshimura, Akari
Hirota, Kouji
Seki, Masayuki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2025, 752

← 1 2 3 4 5 →