The Immunometabolic Roles of Various Fatty Acids in Macrophages and Lymphocytes

被引：29

作者：

Neto, Jose Cesar Rosa ^{[1
,2
]}

Calder, Philip C. ^{[3
,4
,5
,6
]}

Curi, Rui ^{[7
]}

Newsholme, Philip ^{[8
,9
]}

Sethi, Jaswinder K. ^{[3
,4
,5
,6
]}

Silveira, Loreana S. ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Biomed Sci, Dept Cell Biol & Dev, Immunometab Res Grp, BR-05508000 Sao Paulo, Brazil

[2] Univ Sao Paulo, LIM 26, Hosp Clin, BR-01246903 Sao Paulo, Brazil

[3] Univ Southampton, Fac Med, Sch Human Dev & Hlth, Southampton SO16 6YD, Hants, England

[4] Univ Southampton, Natl Inst Hlth Res Southampton Biomed Res Ctr, Southampton SO16 6YD, Hants, England

[5] Univ Hosp Southampton Natl Hlth Serv NHS Fdn Trus, Southampton SO16 6YD, Hants, England

[6] Univ Southampton, Inst Life Sci, Southampton SO17 1BJ, Hants, England

[7] Univ Cruzeiro Sul, Interdisciplinary Postgrad Program Hlth Sci, BR-01506000 Sao Paulo, Brazil

[8] Curtin Univ, Curtin Med Sch, Perth, WA 6102, Australia

[9] Curtin Univ, Curtin Hlth Innovat Res Inst, Perth, WA 6102, Australia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 16期

基金：

巴西圣保罗研究基金会;

关键词：

immune cells; lipids; fatty acids; metabolism; leukocytes; macrophages; lymphocytes; inflammation; cytokines; T-CELL MEMORY; NF-KAPPA-B; METABOLIC-REGULATION; PERIPHERAL-BLOOD; GLUCOSE-METABOLISM; PPAR-GAMMA; INFLAMMATION; OBESE; ACTIVATION; EXPRESSION;

D O I：

10.3390/ijms22168460

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Macrophages and lymphocytes demonstrate metabolic plasticity, which is dependent partly on their state of activation and partly on the availability of various energy yielding and biosynthetic substrates (fatty acids, glucose, and amino acids). These substrates are essential to fuel-based metabolic reprogramming that supports optimal immune function, including the inflammatory response. In this review, we will focus on metabolism in macrophages and lymphocytes and discuss the role of fatty acids in governing the phenotype, activation, and functional status of these important cells. We summarize the current understanding of the pathways of fatty acid metabolism and related mechanisms of action and also explore possible new perspectives in this exciting area of research.

引用

页数：16

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