Cyclodextrins: More than Pharmaceutical Excipients

被引：26
|
作者：
Otero-Espinar, F. J. [1 ]
Luzardo-Alvarez, A. [1 ]
Blanco-Mendez, J. [1 ]
机构：
[1] Univ Santiago de Compostela, Dept Farm & Tecnol Farmaceut, Fac Farm, Santiago De Compostela 15782, Spain
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2010年 / 10卷 / 08期
关键词：
Cyclodextrins; protein refolding; Bacillus anthracis; Cryptosporidium spp; Human Immunodeficiency Virus; immunomodulation; Leishmania spp; Plasmodium spp; IMMUNODEFICIENCY-VIRUS TYPE-1; VIRION-ASSOCIATED CHOLESTEROL; CHLORIDE-DENATURED RHODANESE; IN-VIVO EFFICACY; BETA-CYCLODEXTRIN; LIPID RAFTS; GUANIDINIUM CHLORIDE; ARTIFICIAL CHAPERONE; MEMBRANE CHOLESTEROL; EXPERIMENTAL CRYPTOSPORIDIOSIS;
D O I：
10.2174/138955710791572479
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Cyclodextrins are pharmaceutical excipients used to enhance the solubility, stability, safety and bioavailability of drugs. Recent findings have shown them to display adjuvant activity in vaccine therapy and prophylactic and therapeutic activity in the treatment of several host-pathogen infections. This article focuses on their activity and mechanism of action.
引用
收藏
页码：715 / 725
页数：11
相关论文
共 50 条
  • [21] THE SUITABILITY OF CYCLODEXTRINS AS EXCIPIENTS IN OPHTHALMIC INDOMETHACIN SOLUTION
    VANDOORNE, H
    LERK, CF
    [J]. PHARMACEUTISCH WEEKBLAD-SCIENTIFIC EDITION, 1988, 10 (02) : 100 - 100
  • [22] Pharmaceutical Excipients - No "Inert" Substances
    Roehrdanz, Elke
    Olejniczak, Klaus
    [J]. PHARMAZEUTISCHE INDUSTRIE, 2009, 71 (04): : 661 - +
  • [23] A comprehensive review on pharmaceutical excipients
    Pockle, Rachana D.
    Masareddy, Rajashree S.
    Patil, Archana S.
    Patil, Pragati D.
    [J]. THERAPEUTIC DELIVERY, 2023, 14 (07) : 443 - 458
  • [24] COMPENDIAL STANDARDS FOR PHARMACEUTICAL EXCIPIENTS
    SHANGRAW, RF
    [J]. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1987, 13 (13) : 2421 - 2439
  • [25] Cyclodextrins and their pharmaceutical applications
    Loftsson, Thorsteinn
    Duchene, Dominique
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2007, 329 (1-2) : 1 - 11
  • [26] CYCLODEXTRINS IN THE PHARMACEUTICAL FIELD
    BEKERS, O
    UIJTENDAAL, EV
    BEIJNEN, JH
    BULT, A
    UNDERBERG, WJM
    [J]. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1991, 17 (11) : 1503 - 1549
  • [27] Interfacial behaviour of pharmaceutical excipients
    Dredán, J
    Antal, I
    Rácz, I
    Marton, S
    [J]. FROM COLLOIDS TO NANOTECHNOLOGY, 2004, 125 : 111 - 116
  • [28] CHARACTERIZATION OF MACROMOLECULES USED AS PHARMACEUTICAL EXCIPIENTS - EXCIPIENTS AND THE REGULATORY AUTHORITIES
    MATTHEWS, BR
    [J]. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1990, 16 (17) : 2449 - 2463
  • [29] MORE ON EXCIPIENTS AND ADDITIVES
    NAPKE, E
    STEVENS, DGH
    [J]. CANADIAN MEDICAL ASSOCIATION JOURNAL, 1985, 132 (05) : 509 - 509
  • [30] Developing a biotech costs more than developing a pharmaceutical
    不详
    [J]. BIOPHARM INTERNATIONAL, 2006, 19 (12) : 12 - 12
12345