Cyclodextrins: More than Pharmaceutical Excipients

被引：26
|
作者：
Otero-Espinar, F. J. [1 ]
Luzardo-Alvarez, A. [1 ]
Blanco-Mendez, J. [1 ]
机构：
[1] Univ Santiago de Compostela, Dept Farm & Tecnol Farmaceut, Fac Farm, Santiago De Compostela 15782, Spain
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2010年 / 10卷 / 08期
关键词：
Cyclodextrins; protein refolding; Bacillus anthracis; Cryptosporidium spp; Human Immunodeficiency Virus; immunomodulation; Leishmania spp; Plasmodium spp; IMMUNODEFICIENCY-VIRUS TYPE-1; VIRION-ASSOCIATED CHOLESTEROL; CHLORIDE-DENATURED RHODANESE; IN-VIVO EFFICACY; BETA-CYCLODEXTRIN; LIPID RAFTS; GUANIDINIUM CHLORIDE; ARTIFICIAL CHAPERONE; MEMBRANE CHOLESTEROL; EXPERIMENTAL CRYPTOSPORIDIOSIS;
D O I：
10.2174/138955710791572479
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Cyclodextrins are pharmaceutical excipients used to enhance the solubility, stability, safety and bioavailability of drugs. Recent findings have shown them to display adjuvant activity in vaccine therapy and prophylactic and therapeutic activity in the treatment of several host-pathogen infections. This article focuses on their activity and mechanism of action.
引用
收藏
页码：715 / 725
页数：11
相关论文
共 50 条
  • [1] Lumichrome complexation by cyclodextrins: Influence of pharmaceutical excipients
    Lilletvedt, M.
    Kristensen, S.
    Tonnesen, H. H.
    [J]. PHARMAZIE, 2010, 65 (12): : 871 - 876
  • [2] Use of cyclodextrins as excipients in pharmaceutical products: why not in extemporaneous preparations?
    Ramos-Martinez, Beatriz
    Davila-Pousaz, Carmelo
    Merino-Bohorquez, Vicente
    Garcia-Palomoo, Marta
    Pilar Flox-Benitez, Ma
    [J]. FARMACIA HOSPITALARIA, 2022, 46 (01) : 31 - 39
  • [3] Cyclodextrins: Only Pharmaceutical Excipients or Full-Fledged Drug Candidates?
    Kovacs, Tamas
    Nagy, Peter
    Panyi, Gyorgy
    Szente, Lajos
    Varga, Zoltan
    Zakany, Florina
    [J]. PHARMACEUTICS, 2022, 14 (12)
  • [4] Review of Applications of Cyclodextrins as Taste-Masking Excipients for Pharmaceutical Purposes
    Adamkiewicz, Lena
    Szeleszczuk, Lukasz
    [J]. MOLECULES, 2023, 28 (19):
  • [5] Novel excipients needed more than ever before
    Challener, Cynthia A.
    [J]. Pharmaceutical Technology, 2021, 45 (03) : 24 - 29
  • [6] Pharmaceutical excipients
    不详
    [J]. AGRO FOOD INDUSTRY HI-TECH, 1997, 8 (06): : 51 - 51
  • [7] Pharmaceutical excipients
    不详
    [J]. CHIMICA OGGI-CHEMISTRY TODAY, 1997, 15 (3-4) : 75 - 75
  • [8] Pharmaceutical excipients
    Beran, Roy G.
    [J]. AUSTRALIAN PRESCRIBER, 2012, 35 (01) : 5 - 6
  • [9] Cyclodextrins as excipients in tablet formulations
    Conceicao, Jaime
    Adeoye, Oluwatomide
    Cabral-Marques, Helena Maria
    Sousa Lobo, Jose Manuel
    [J]. DRUG DISCOVERY TODAY, 2018, 23 (06) : 1274 - 1284
  • [10] HANDBOOK OF PHARMACEUTICAL EXCIPIENTS
    COOPER, J
    [J]. PHARMACY INTERNATIONAL, 1981, 2 (03): : R4 - R4
12345