Stereoselective synthesis of antifungal sulfoximines, novel triazoles, II

被引：0

作者：

Kawanishi, H ^{[1
]}

Morimoto, H ^{[1
]}

Nakano, T ^{[1
]}

Watanabe, T ^{[1
]}

Oda, K ^{[1
]}

Tsujihara, K ^{[1
]}

机构：

[1] Tanabe Seiyaku Co Ltd, Discovery Res Lab, Toda, Saitama 3358505, Japan

来源：

HETEROCYCLES | 1998年 / 49卷

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel triazole derivatives with N-substituted sulfoximine moiety were synthesized and evaluated for antifungal activity. These compounds showed only significantly weak activity and the N-H sulfoximine moiety was extremely important for the activity. A more practical and effective stereoselective synthesis of N-H sulfoximine, (R)-S-2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydoroxy-4-(1H-1,2,4-triazol-1-yl)]butyl-S-methylsulfoximine (1), which was considered to be the most promising compound, has been developed.

引用

页码：181 / 189

页数：9

共 50 条

[41] SYNTHESIS OF N,N'-DITHIOBIS-SULFOXIMINES, SULFINYLBIS-SULFOXIMINES AND SULFONYLBIS-SULFOXIMINES
OKAHARA, M
YOSHIKAWA, E
IKEDA, I
KOMORI, S
SYNTHESIS-STUTTGART, 1975, (08): : 521 - 522
[42] Ru(II)-Catalyzed Asymmetric Synthesis of S-Chiral Heterocyclic Sulfoximines
Wu, Qiong
Shi, Feng
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 41 (08) : 3339 - 3341
[43] Stereoselective degradation behavior of the novel chiral antifungal agrochemical penthiopyrad in soil
Liu, Zhengyi
Chen, Dan
Han, Jiahua
Chen, Ye
Zhang, Kankan
ENVIRONMENTAL RESEARCH, 2021, 194
[44] Sulfoximines: Synthesis and catalytic applications
Okamura, H
Bolm, C
CHEMISTRY LETTERS, 2004, 33 (05) : 482 - 487
[45] Synthesis, Antibacterial and Antifungal Activity of Some Novel 3,5-Disubstituted-1H-1,2,4-triazoles
Sharma, Shweta
Gangal, Saloni
Rauf, Abdul
Zahin, Maryam
ARCHIV DER PHARMAZIE, 2008, 341 (11) : 714 - 720
[46] Comparison of in vitro antifungal activity of novel triazoles with available antifungal agents against dermatophyte species caused tinea pedis
Salehi, Z.
Fatahi, N.
Taran, M.
Izadi, A.
Badali, H.
Hashemi, S. J.
Ghazvini, S. Daie
Daie, R.
Ghaffari, M.
Aala, F.
Barac, A.
Khodavaisy, S.
JOURNAL DE MYCOLOGIE MEDICALE, 2020, 30 (02):
[47] Stereoselective synthesis of a novel carbocyclic nucleoside
Gurjar, MK
Maheshwar, K
JOURNAL OF ORGANIC CHEMISTRY, 2001, 66 (22): : 7552 - 7554
[48] A novel, stereoselective and convergent synthesis of aryltetralins
Miles, SM
Marsden, SP
Leatherbarrow, RJ
Coates, WJ
CHEMICAL COMMUNICATIONS, 2004, (20) : 2292 - 2293
[49] Stereoselective synthesis of novel thioglycosyl heterocycles
El Ashry, El Sayed H.
Awad, Laila F.
Abd Al Moaty, Mohamed N.
Ghabbour, Hazem A.
Barakatdt, Assem
JOURNAL OF MOLECULAR STRUCTURE, 2018, 1152 : 87 - 95
[50] A NOVEL STEREOSELECTIVE SYNTHESIS OF CONJUGATED DIENONES
MA, DW
LIN, YR
LU, XY
YU, YH
TETRAHEDRON LETTERS, 1988, 29 (09) : 1045 - 1048

← 1 2 3 4 5 →