Stereoselective synthesis of antifungal sulfoximines, novel triazoles, II

被引：0

作者：

Kawanishi, H ^{[1
]}

Morimoto, H ^{[1
]}

Nakano, T ^{[1
]}

Watanabe, T ^{[1
]}

Oda, K ^{[1
]}

Tsujihara, K ^{[1
]}

机构：

[1] Tanabe Seiyaku Co Ltd, Discovery Res Lab, Toda, Saitama 3358505, Japan

来源：

HETEROCYCLES | 1998年 / 49卷

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel triazole derivatives with N-substituted sulfoximine moiety were synthesized and evaluated for antifungal activity. These compounds showed only significantly weak activity and the N-H sulfoximine moiety was extremely important for the activity. A more practical and effective stereoselective synthesis of N-H sulfoximine, (R)-S-2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydoroxy-4-(1H-1,2,4-triazol-1-yl)]butyl-S-methylsulfoximine (1), which was considered to be the most promising compound, has been developed.

引用

页码：181 / 189

页数：9

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