Reactive Oxygen Species Explicit Dosimetry (ROSED) for Fractionated Photofrin-mediated Photodynamic Therapy

被引：0
|
作者：
Sun, Hongjing [1 ]
Ong, Yi Hong [1 ]
Zhu, Timothy C. [1 ]
机构：
[1] Univ Penn, Perelman Ctr Adv Med PCAM, Dept Radiat Oncol, Philadelphia, PA 19104 USA
来源：
OPTICAL METHODS FOR TUMOR TREATMENT AND DETECTION: MECHANISMS AND TECHNIQUES IN PHOTODYNAMIC AND PHOTOBIOMODULATION THERAPY XXX | 2022年 / 11940卷
关键词：
photodynamic therapy; Photofrin; reactive oxygen species; explicit dosimetry; light fractionation; RESPONSES; ACID;
D O I：
10.1117/12.2609969
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Photodynamic therapy (PDT) is an established modality for cancer treatment and reactive oxygen species explicit dosimetry (ROSED), based on direct measurements of in-vivo light fluence (rate), in-vivo photofrin concentration, and tissue oxygenation concentration, has been proved to be an effective dosimetric quantity which can be used to predict PDT outcome. In this study, ROSED was performed for photofrin-mediated PDT for mice bearing radiation-induced fibrosacorma (RIF) tumor. PDT treatments were performed using single or fractionated illumination to a same total fluence of 135 Jcm(-2). The effects of light fractionation on the total reacted [ROS](rx) and treatment outcomes were evaluated.
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页数：6
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