Diversifying microbial natural products for drug discovery

被引：122

作者：

Knight, V ^{[1
]}

Sanglier, JJ ^{[1
]}

DiTullio, D ^{[1
]}

Braccili, S ^{[1
]}

Bonner, P ^{[1
]}

Waters, J ^{[1
]}

Hughes, D ^{[1
]}

Zhang, L ^{[1
]}

机构：

[1] Cetek Corp, Marlborough, MA 01752 USA

来源：

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | 2003年 / 62卷 / 5-6期

关键词：

D O I：

10.1007/s00253-003-1381-9

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Historically, nature has provided the source for the majority of the drugs in use today. More than 20,000 microbial secondary metabolites have been described, but only a small percentage of these have been carried forward as natural product drugs. Natural products are in tough competition with large chemical libraries and with combinatorial chemistries. Hence, each step of a natural product program has to be more efficient than ever, starting from the collection of environmental samples and the selection of strains, to metabolic expression, genetic exploitation, sample preparation and chemical dereplication. This review will focus on approaches for diversifying microbial natural product strains and extract libraries, while decreasing genetic and chemical redundancy.

引用

下载

页码：446 / 458

页数：13

共 50 条

[31] Natural products: A lead for drug discovery and development
Chopra, Bhawna
Dhingra, Ashwani Kumar
PHYTOTHERAPY RESEARCH, 2021, 35 (09) : 4660 - 4702
[32] Drug discovery from natural products.
不详
Nature Reviews Drug Discovery, 2009, 8 (8) : 678 - 678
[33] Rediscovering the role of natural products in drug discovery
Desai, Manoj C.
Chackalamannil, Samuel
CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, 2008, 11 (04) : 436 - 437
[34] Antimalarial natural products drug discovery in Panama
Calderon, Angela I.
Simithy-Williams, Johayra
Gupta, Mahabir P.
PHARMACEUTICAL BIOLOGY, 2012, 50 (01) : 61 - 71
[35] Privileged Scaffolds in Natural Products and Drug Discovery
Sun, Dianqing
Guendisch, Daniela
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2016, 16 (11) : 1199 - 1199
[36] The future role of natural products in drug discovery
Buss, AD
BIOASSAY METHODS IN NATURAL PRODUCT RESEARCH AND DRUG DEVELOPMENT, 1999, 43 : 183 - 193
[37] Importance of microbial natural products and the need to revitalize their discovery
Demain, Arnold L.
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 2014, 41 (02) : 185 - 201
[38] The evolving role of natural products in drug discovery
Frank E. Koehn
Guy T. Carter
Nature Reviews Drug Discovery, 2005, 4 : 206 - 220
[39] Natural products in drug discovery and human health
Maria-José U. Ferreira
Phytochemistry Reviews, 2021, 20 : 1 - 4
[40] The role of natural products in modern drug discovery
Calixto, Joao R.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS, 2019, 91

← 1 2 3 4 5 →