Diversifying microbial natural products for drug discovery

被引：123

作者：

Knight, V ^{[1
]}

Sanglier, JJ ^{[1
]}

DiTullio, D ^{[1
]}

Braccili, S ^{[1
]}

Bonner, P ^{[1
]}

Waters, J ^{[1
]}

Hughes, D ^{[1
]}

Zhang, L ^{[1
]}

机构：

[1] Cetek Corp, Marlborough, MA 01752 USA

来源：

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | 2003年 / 62卷 / 5-6期

关键词：

D O I：

10.1007/s00253-003-1381-9

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Historically, nature has provided the source for the majority of the drugs in use today. More than 20,000 microbial secondary metabolites have been described, but only a small percentage of these have been carried forward as natural product drugs. Natural products are in tough competition with large chemical libraries and with combinatorial chemistries. Hence, each step of a natural product program has to be more efficient than ever, starting from the collection of environmental samples and the selection of strains, to metabolic expression, genetic exploitation, sample preparation and chemical dereplication. This review will focus on approaches for diversifying microbial natural product strains and extract libraries, while decreasing genetic and chemical redundancy.

引用

页码：446 / 458

页数：13

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J.-J. Sanglier
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J. Waters
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L. Zhang
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