6-Hydroxydopamine: a far from simple neurotoxin

被引：42
|
作者：
Vareslija, Damir [1 ,2 ]
Tipton, Keith F. [1 ]
Davey, Gavin P. [1 ]
McDonald, Andrew G. [1 ]
机构：
[1] Trinity Coll Dublin, Sch Biochem & Immunol, Dublin 2, Ireland
[2] Royal Coll Surgeons Ireland, Dept Surg, York House, York St, Dublin, Ireland
来源：
JOURNAL OF NEURAL TRANSMISSION | 2020年 / 127卷 / 02期
基金：
爱尔兰科学基金会;
关键词：
Neurotoxicity; Aminochrome; Apoptosis; Autoxidation; Dopamine; Highly reactive oxygen species (hROS); 4-Hydroxynonenal; Mitochondria; Iron release; Necrosis; Oxidative damage; Parkinson's disease; Peroxynitrite; Reactive oxygen species (ROS); NEURONAL CELL-DEATH; CATECHOL-O-METHYLTRANSFERASE; UNFOLDED PROTEIN RESPONSE; NF-KAPPA-B; MONOAMINE-OXIDASE; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; DOPAMINERGIC-NEURONS; PARKINSONS-DISEASE; OXIDATIVE STRESS; COMPLEX-I;
D O I：
10.1007/s00702-019-02133-6
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
6-Hydroxydopamine (6-OHDA), which is a neurotoxin that selectively destroys catecholaminergic nerves in sympathetically innervated tissues, has been used to provide a model of Parkinson's disease in experimental animals. It is rapidly autoxidised to yield potentially toxic products and reactive oxygen species. Its ability to release Fe(II) from protein storage sites also results in the formation of hROS. This account will consider how this family of toxic products may contribute to the observed effects of 6-OHDA.
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页码：213 / 230
页数：18
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