Effects of Levofloxacin on Blood Lymphocyte Apoptosis in Patients with Pulmonary Tuberculosis: an In Vitro Study

被引：5
|
作者：
Serebryakova, V. A. [1 ]
Urazova, O. I. [1 ]
Novitsky, V. V. [1 ]
Vengerovskii, A. I. [1 ]
Kononova, T. E. [1 ]
Vasil'eva, O. A. [1 ]
Beresneva, A. E. [1 ]
机构：
[1] Siberian State Med Univ, Minist Hlth Russian Federat, Tomsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2019年 / 168卷 / 01期
关键词：
fluroquinolones; tuberculosis; lymphocytes; programmed cell death; CELLS;
D O I：
10.1007/s10517-019-04659-x
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effects of a fluroquinolone levofloxacin on apoptosis of peripheral blood lymphocytes from patients with infiltrative pulmonary tuberculosis were studied in vitro. It was found that levofloxacin stimulated apoptotic cell death in tuberculosis. Addition of levofloxacin to cell suspension from patients with drug-susceptible form of tuberculosis led to an increase in the number of CD95(+) and AnnV(+) lymphocytes. In patients with drug-resistant form of tuberculosis, only the number of apoptotic lymphocytes, but not the count of CD95(+) cells increased under these conditions.
引用
收藏
页码：109 / 112
页数：4
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