Effect of adjuvant tamoxifen therapy on thyroid function in postmenopausal women with breast cancer

被引：23
|
作者：
Zidan, J
Rubenstein, W
机构：
[1] Rebecca Sief Govt Hosp, Oncol Unit, IL-13100 Safed, Israel
[2] Technion Israel Inst Technol, Fac Med, Haifa, Israel
来源：
ONCOLOGY | 1999年 / 56卷 / 01期
关键词：
tamoxifen; adjuvant therapy; breast cancer; thyroid function;
D O I：
10.1159/000011928
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Serum thyroid-stimulating hormone (TSH), free thyroxine (FT4) and total tri-iodothyronine (TT3) concentrations were measured in 45 postmenopausal breast cancer patients before adjuvant treatment with tamoxifen and at 3- and 6-month intervals, A significant increase in TSH (p = 0.002) at the end of 3 months and a subsequent decrease at the end of 6 months was noted. There were no significant changes in TT3 and FT4. We concluded that tamoxifen therapy in postmenopausal women may result in a reversible increase in TSH after 3 months.
引用
收藏
页码：43 / 45
页数：3
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