Potent divalent inhibitors with rigid glucose click spacers for Pseudomonas aeruginosa lectin LecA

被引：72
|
作者：
Pertici, Francesca [1 ]
Pieters, Roland J. [1 ]
机构：
[1] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Dept Med Chem & Chem Biol, NL-3508 TB Utrecht, Netherlands
来源：
CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 33期
关键词：
BACTERIAL LECTIN; STRUCTURAL BASIS; HIGH-AFFINITY; MULTIVALENT; RECOGNITION; BINDING; PENTAVALENT; DENDRIMERS; PROSTATE; LIGANDS;
D O I：
10.1039/c2cc30234a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The synthesis of a new rigid spacer based on carbohydrate-triazole repeating units and their incorporation into divalent systems is described. Inhibition studies showed that a well-matched system with a rigid spacer with flexible ends leads to the most potent inhibition of Pseudomonas aeruginosa lectin LecA.
引用
收藏
页码：4008 / 4010
页数：3
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