Activation of either PAR1 or PAR4 on human platelets can elicit expression of maximum platelet procoagulant activity.

被引：0
|
作者：
Heger, CD [1 ]
Mosley, CN [1 ]
Tracy, PB [1 ]
机构：
[1] Univ Vermont, Coll Med, Burlington, VT USA
来源：
BLOOD | 2001年 / 98卷 / 11期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
2163
引用
收藏
页码：518A / 518A
页数：1
相关论文
共 50 条
  • [41] A novel mechanism regulating human platelet activation by MMP-2-mediated PAR1 biased signaling
    Sebastiano, Manuela
    Momi, Stefania
    Falcinelli, Emanuela
    Bury, Loredana
    Hoylaerts, Marc F.
    Gresele, Paolo
    BLOOD, 2017, 129 (07) : 883 - 895
  • [42] Activation of Apoptosis Signal-regulating Kinase 1 (ASK1) Occurs Downstream of PAR4 and TP-α Receptors in Human Platelets
    Derstine, Randall J.
    Naik, Meghna U.
    Turaga, Ramya
    Naik, Ulhas P.
    FASEB JOURNAL, 2016, 30
  • [43] Activation of protease-activated receptor (PAR) 1 by frog trefoil factor (TFF) 2 and PAR4 by human TFF2
    Yong Zhang
    Guoyu Yu
    Yanjie Wang
    Yang Xiang
    Qian Gao
    Ping Jiang
    Jie Zhang
    Wenhui Lee
    Yun Zhang
    Cellular and Molecular Life Sciences, 2011, 68 : 3771 - 3780
  • [44] Activation of protease-activated receptor (PAR) 1 by frog trefoil factor (TFF) 2 and PAR4 by human TFF2
    Zhang, Yong
    Yu, Guoyu
    Wang, Yanjie
    Xiang, Yang
    Gao, Qian
    Jiang, Ping
    Zhang, Jie
    Lee, Wenhui
    Zhang, Yun
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2011, 68 (22) : 3771 - 3780
  • [45] Platelet PAR4 associated with neutral sphingomyelinase responsible for thrombin-stimulated ceramide-NF-kappaB signaling in human platelets
    Sheu, J. -R.
    Chen, W. -F.
    FEBS JOURNAL, 2013, 280 : 271 - 271
  • [46] Oligosaccharide Blocks PAR1 (Proteinase-Activated Receptor 1)-PAR4-Mediated Platelet Activation by Binding to Thrombin Exosite II and Impairs Thrombosis
    Li, Sujuan
    Wang, Weili
    Lin, Lisha
    Yang, Lian
    Cai, Ying
    Yang, Xingzhi
    Zhang, Taocui
    Xiao, Chuang
    Yan, Hui
    Gao, Na
    Zhao, Jinhua
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2023, 43 (02) : 253 - 266
  • [47] The Common PAR4 Ala120Thr Variant Has a Major Effect on Platelet Reactivity to Thrombin and These Effects Are Enhanced with PAR1 and P2Y12 Inhibition
    Whitley, Michael J.
    Vesci, Joanne
    Holinstat, Michael
    Edelstein, Leonard C.
    Bray, Paul F.
    BLOOD, 2016, 128 (22)
  • [48] Combined blockade of thrombin anion binding exosite-1 and PAR4 produces synergistic antiplatelet effect in human platelets
    Wu, Chin-Chung
    Wang, Wei-Ya
    Wei, Chien-Kei
    Teng, Che-Ming
    THROMBOSIS AND HAEMOSTASIS, 2011, 105 (01) : 88 - 95
  • [49] Release reaction of brain-derived neurotrophic factor (BDNF) through PAR1 activation and its two distinct pools in human platelets
    Tamura, S.
    Suzuki, H.
    Hirowatari, Y.
    Nagasawa, A.
    Hatase, M.
    Tsunematsu, T.
    Matsuno, K.
    Kobayashi, S.
    Moriyama, T.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2011, 9 : 525 - 525
  • [50] Release reaction of brain-derived neurotrophic factor (BDNF) through PAR1 activation and its two distinct pools in human platelets
    Tamura, Shogo
    Suzuki, Hidenori
    Hirowatari, Yuji
    Hatase, Masanao
    Nagasawa, Ayumi
    Matsuno, Kazuhiko
    Kobayashi, Seiichi
    Moriyama, Takanori
    THROMBOSIS RESEARCH, 2011, 128 (05) : E55 - E61
12345