Facile and efficient synthesis of 2-substituted-N1-carbethoxy-2,3-dihydro-4(1H)-quinazolinones in fluorous solvent

被引：8

作者：

Xu, Bai Ling ^{[1
]}

Chen, Jin Ping ^{[2
]}

Qiao, Rong Zhang ^{[3
]}

Fu, De Cai ^{[2
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, Peking Union Med Coll, Beijing 100050, Peoples R China

[2] Hebei Univ Sci & Technol, Shijiazhuang 050018, Peoples R China

[3] Beijing Univ Chem Technol, Dept Life Sci & Technol, Beijing 100029, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2008年 / 19卷 / 05期

基金：

中国国家自然科学基金;

关键词：

quinazolinones; trifluoroethanol; hexafluoroisopropanol; fluorous solvent; solvent effect;

D O I：

10.1016/j.cclet.2008.03.022

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A facile, efficient and novel approach to access 2-substituted-N1-carbethoxy-2,3-dihydro-4(1H)-quinazolinones was developed by condensation of substituted N-carbethoxyanthranilamide with alkyl, aromatic or heteroaromatic aldehydes in the refluxing 2,2,2-trifluoroethanol or hexafluoroisopropanol using p-toluenesulfonic acid as catalyst. (C) 2008 Bai Ling Xu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：537 / 540

页数：4

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