Facile and efficient synthesis of 2-substituted-N1-carbethoxy-2,3-dihydro-4(1H)-quinazolinones in fluorous solvent

被引：8
|
作者：
Xu, Bai Ling [1 ]
Chen, Jin Ping [2 ]
Qiao, Rong Zhang [3 ]
Fu, De Cai [2 ]
机构：
[1] Chinese Acad Med Sci, Inst Mat Med, Peking Union Med Coll, Beijing 100050, Peoples R China
[2] Hebei Univ Sci & Technol, Shijiazhuang 050018, Peoples R China
[3] Beijing Univ Chem Technol, Dept Life Sci & Technol, Beijing 100029, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2008年 / 19卷 / 05期
基金：
中国国家自然科学基金;
关键词：
quinazolinones; trifluoroethanol; hexafluoroisopropanol; fluorous solvent; solvent effect;
D O I：
10.1016/j.cclet.2008.03.022
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A facile, efficient and novel approach to access 2-substituted-N1-carbethoxy-2,3-dihydro-4(1H)-quinazolinones was developed by condensation of substituted N-carbethoxyanthranilamide with alkyl, aromatic or heteroaromatic aldehydes in the refluxing 2,2,2-trifluoroethanol or hexafluoroisopropanol using p-toluenesulfonic acid as catalyst. (C) 2008 Bai Ling Xu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
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页码：537 / 540
页数：4
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