AChE inhibitor: A regio- and stereo-selective 1,3-dipolar cycloaddition for the synthesis of novel substituted 5,6-dimethoxy spiro[5.3′]-oxindole-spiro-[6.3"]-2,3-dihydro-1H-inden-1"-one-7-(substituted aryl)-tetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole

被引：49

作者：

Ali, Mohamed Ashraf ^{[1
]}

Ismail, Rusli ^{[1
]}

Choon, Tan Soo ^{[1
]}

Kumar, Raju Suresh ^{[2
]}

Osman, Hasnah ^{[2
]}

Arumugam, Natarajan ^{[3
]}

Almansour, Abdulrahman I. ^{[3
]}

Elumalai, Karthikeyan ^{[5
]}

Singh, Abhimanyu ^{[4
]}

机构：

[1] Univ Sains Malaysia, Inst Res Mol Med, Minden 11800, Penang, Malaysia

[2] Univ Sains Malaysia, Sch Chem Sci, Minden 11800, Penang, Malaysia

[3] King Saud Univ, Dept Chem, Coll Sci, Riyadh 11451, Saudi Arabia

[4] Alwar Pharm Coll, Dept Med Chem, Alwar 301030, Rajasthan, India

[5] Sunrise Univ, Fac Pharm, Dept Drug Discovery Res, Alwar 301030, Rajasthan, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 01期

关键词：

Alzheimer diseases; Acetyl cholinesterase; AchE inhibitor; 1,3-Dipolar cycloaddition; Azomethine ylide;

D O I：

10.1016/j.bmcl.2011.10.087

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Pyrrolothiazolyloxindole analogues share vital pharmacological properties, considered useful in Alzheimer's disease (AD). The aim of this study was synthesis and evaluate pyralothiazolyloxindole analogues if possess acetyl cholinesterase (AChE) inhibitory activity. The easily accessible one-pot synthesis of these compounds resulted to be significantly less difficult and expensive than that of donepezil. Several compounds possess anti-cholinesterase activity in the order of micro and sub-micromolar. Particularly, compound 6a was the most potent inhibitors of the series against acetyl cholinesterase enzyme with IC50 0.11 mu mol/L. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：508 / 511

页数：4

共 49 条

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Mojahidi, Souad
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JOURNAL OF CHEMISTRY, 2013, 2013
[33] 1, 3-Dipolar cycloaddition reactions: Synthesis of 5-benzyl-1-(2′,4′-dibromophenyl)-3-(4″-substituted phenyl)-3a,4,6,6a-tetrahydro-1H, 5H-pyrrolo[3,4-c]pyrazole-4,6-dione derivatives
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BALJIT SINGH
Journal of Chemical Sciences, 2013, 125 : 1529 - 1534
[34] 1, 3-Dipolar cycloaddition reactions: Synthesis of 5-benzyl-1-(2′,4′-dibromophenyl)-3-(4"-substituted phenyl)-3a,4,6,6a-tetrahydro-1H, 5H-pyrrolo[3,4-c]pyrazole-4,6-dione derivatives
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JOURNAL OF CHEMICAL RESEARCH, 2009, (04) : 240 - 243
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (15) : 4451 - 4453
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[39] Crystal structures of 6a,6b,7,11a-tetrahydro-6H,9H-spiro[chromeno[3′,4′:3,4]pyrrolo[1,2-c]-thiazole-11,3′-indoline]-2′,6-dione and 5′-methyl-6a,6b,7,11a-tetrahydro-6H,9H-spiro[chromeno-[3′,4′:3,4] pyrrolo[1,2-c]thiazole-11,3′-indoline]-2′,6-dione
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