α7 nicotinic acetylcholine receptors in the hippocampal circuit: taming complexity

被引：29
|
作者：
Letsinger, Ayland C. [1 ]
Gu, Zhenglin [1 ]
Yakel, Jerrel L. [1 ]
机构：
[1] NIEHS, Neurobiol Lab, NIH, US Dept HHS, POB 12233, Durham, NC 27709 USA
来源：
TRENDS IN NEUROSCIENCES | 2022年 / 45卷 / 02期
基金：
美国国家卫生研究院;
关键词：
ALZHEIMERS-DISEASE; GLUTAMATERGIC TRANSMISSION; CHOLINERGIC MODULATION; SUSTAINED ATTENTION; ENTORHINAL CORTEX; NMDA RECEPTORS; NACH RECEPTORS; ACH RECEPTORS; ACTIVATION; NEURONS;
D O I：
10.1016/j.tins.2021.11.006
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Cholinergic innervation of the hippocampus uses the neurotransmitter acetylcholine (ACh) to coordinate neuronal circuit activity while simultaneously influencing the function of non-neuronal cell types. The alpha 7 nicotinic ACh receptor (nAChR) subtype is highly expressed throughout the hippocampus, has the highest calcium permeability compared with other subtypes of nAChRs, and is of high therapeutic interest due to its association with a variety of neurological disorders and neurodegenerative diseases. In this review, we synthesize research describing alpha 7 nAChR properties, function, and relationship to cognitive dysfunction within the hippocampal circuit and highlight approaches to help improve therapeutic development.
引用
收藏
页码：145 / 157
页数：13
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