Cyclosporine alters correlation between free and total mycophenolic acid in kidney transplant recipients in the initial phase

被引：4
|
作者：
Mino, Y. [1 ]
Naito, T. [1 ]
Otsuka, A. [2 ]
Takayama, T. [2 ]
Ozono, S. [2 ]
Kagawa, Y. [3 ]
Kawakami, J. [1 ]
机构：
[1] Hamamatsu Univ Sch Med, Dept Hosp Pharm, Higashi Ku, Hamamatsu, Shizuoka 4313192, Japan
[2] Hamamatsu Univ Sch Med, Dept Urol, Higashi Ku, Hamamatsu, Shizuoka 4313192, Japan
[3] Univ Shizuoka, Grad Sch Pharmaceut Sci, Dept Clin Pharmaceut & Pharm Practice, Suruga Ku, Shizuoka 4228526, Japan
来源：
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS | 2011年 / 36卷 / 02期
关键词：
cyclosporine; free concentration; kidney transplantation; mycophenolic acid; mycophenolic acid glucuronide; RESISTANCE-ASSOCIATED PROTEIN-2; RENAL-TRANSPLANT; GLUCURONIDE METABOLITES; CALCINEURIN INHIBITORS; ACYL GLUCURONIDE; FREE FRACTION; HUMAN PLASMA; MOFETIL; PHARMACOKINETICS; TACROLIMUS;
D O I：
10.1111/j.1365-2710.2010.01168.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
P>What is known and Objective: The factors affecting the pharmacokinetics of free mycophenolic acid (MPA) and its phenolic glucuronide (MPAG) are still unclear. The aim of this study was to evaluate the influence of cyclosporine on the pharmacokinetics of free MPA and MPAG. Methods: Seventy-seven kidney transplant recipients (23 were in an initial phase and 54 in a stable phase; 41 were treated with cyclosporine and 36 with tacrolimus) were enrolled. Free and total MPA and MPAG were determined using HPLC. The correlations between free and total predose concentrations (C-0) of MPA or MPAG were evaluated separately in patients receiving calcineurin inhibitor medications. Results and Discussion: Serum concentration of albumin was lower in the initial phase than in the stable phase. A higher ratio of free MPAG C-0 to free MPA C-0 was observed in cyclosporine-treated than tacrolimus-treated kidney transplant recipients. Free MPA C-0 correlated weakly with total MPA C-0 in kidney transplant recipients treated with cyclosporine in the initial phase (rho = 0 center dot 53, P = 0 center dot 06). What is new and Conclusion: Cyclosporine increased the ratio of free MPAG C-0 to free MPA C-0 and varied the free fraction of MPA in the hypoalbuminaemic kidney transplant recipients in the initial phase.
引用
收藏
页码：217 / 224
页数：8
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