Variations of the proprotein convertase subtilisin/kexin type 9 gene in coronary artery disease

被引：6
|
作者：
Chiang, Shih-Min [1 ]
Yang, Yi-Sun [1 ,2 ,3 ]
Yang, Shun-Fa [1 ,4 ]
Tsai, Chin-Feng [5 ]
Ueng, Kwo-Chnag [3 ,5 ]
机构：
[1] Chung Shan Med Univ, Inst Med, Taichung, Taiwan
[2] Chung Shan Med Univ Hosp, Div Endocrinol & Metab, Dept Internal Med, Taichung, Taiwan
[3] Chung Shan Med Univ, Sch Med, Taichung, Taiwan
[4] Chung Shan Med Univ Hosp, Dept Med Res, Taichung, Taiwan
[5] Chung Shan Med Univ Hosp, Div Cardiol, Dept Internal Med, 110,Sec1,Jianguo N Rd, Taichung 40201, Taiwan
来源：
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2020年 / 48卷 / 01期
关键词：
Proprotein Convertase Subtilisin/Kexin Type 9; coronary artery disease; diabetes; polymorphisms; Taiwanese; genotyping; LIPOPROTEIN CHOLESTEROL LEVELS; PCSK9; GENE; SEQUENCE VARIATIONS; E670G POLYMORPHISM; RISK; MUTATIONS; SEVERITY; LDL;
D O I：
10.1177/0300060519839519
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Objective: Coronary artery disease (CAD) is the principal cause of mortality and morbidity worldwide. Studies have provided controversial results regarding whether variations in the proprotein convertase subtilisin/kexin type 9 gene (PCSK9) are risk factors for CAD. In this study, we evaluated the risk factors associated with PSCK9 genotypes and CAD in the Taiwanese population. Methods: A total of 501 patients diagnosed with CAD by angiography and 334 CAD-free controls were recruited. Two single nucleotide polymorphisms of PSCK9 (rs505151 and rs529787) were genotyped. Results: The prevalence of a positive family history for CAD was significantly higher in individuals carrying the AG+GG genotype of the PSCK9 rs505151 polymorphism. Among CAD patients with a positive family history, the prevalence of diabetes mellitus was significantly higher in those carrying the AG+GG genotype of the PSCK9 rs505151 polymorphism (73.3%) than in those carrying the AA genotype (39.2%). Conclusion: In CAD patients, the AG genotype of PSCK9 rs505151 is associated with diabetes and a positive family history of CAD.
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页数：8
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