The role of mucin-type O-glycans in eukaryotic development

被引：55
|
作者：
Tabak, Lawrence A. [1 ]
机构：
[1] NIDDKD, Sect Biol Chem, NIH, Bethesda, MD 20892 USA
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2010年 / 21卷 / 06期
关键词：
Mucin-type O-glycosylation; Mucins; Glycosyltransferases; UDP-GalNAc:polypeptide; N-acetylgalactosaminyltransferases; O-glycans; POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE; PORCINE SUBMAXILLARY MUCIN; UDP-GALNAC; IGA NEPHROPATHY; DROSOPHILA-MELANOGASTER; LINKED GLYCOSYLATION; SALIVARY MUCINS; NERVOUS-SYSTEM; MOUSE EMBRYOS; C1GALT1; GENE;
D O I：
10.1016/j.semcdb.2010.02.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Newly emerging genetic studies have revealed that a subset of the family of glycosyltransferases responsible for the formation of mucin-typeOglycans is essential for normal development. As additional genetic, biochemical and physical tools are developed to interrogate the complex structure and surface location of this under-studied class of carbohydrate, no doubt additional roles will be elucidated. Published by Elsevier Ltd.
引用
收藏
页码：616 / 621
页数：6
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