CYP2B6 GENOTYPE AFFECTS METHADONE DISPOSITION IN CHILDREN AS DEMONSTRATED BY PHYSIOLOGICALLY BASED PHARMACOKINETIC (PBPK) MODELING.

被引：0
|
作者：
Gerhart, J. [1 ]
Edginton, A. [2 ]
Watt, K. [3 ]
Cohen-Wolkowiez, M. [3 ]
Harper, B. [3 ]
Muller, W. [4 ]
Delmore, P. [5 ]
Atz, A. [6 ]
Payne, E. [7 ]
Erinjeri, J. [7 ]
Lin, S. [7 ]
Gonzalez, D. [1 ]
机构：
[1] Univ N Carolina, Chapel Hill, NC 27515 USA
[2] Univ Waterloo, Kitchener, ON, Canada
[3] Duke Clin Res Inst, Durham, NC USA
[4] Ann & Robert H Lurie Childrens Hosp Chicago, Chicago, IL 60611 USA
[5] Wesley Med Ctr, Wichita, KS USA
[6] Med Univ South Carolina, Charleston, SC 29425 USA
[7] Emmes, Rockville, MD USA
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2020年 / 107卷
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
PII-106
引用
收藏
页码：S64 / S64
页数：1
相关论文
共 50 条
  • [41] Contribution of CYP2B6 alleles in explaining extreme (S)-methadone plasma levels: a CYP2B6 gene resequencing study
    Dobrinas, Maria
    Crettol, Severine
    Oneda, Beatrice
    Lahyani, Rachel
    Rotger, Margalida
    Choong, Eva
    Lubomirov, Rubin
    Csajka, Chantal
    Eap, Chin B.
    PHARMACOGENETICS AND GENOMICS, 2013, 23 (02): : 84 - 93
  • [42] Physiologically Based Pharmacokinetic (PBPK) Modeling to Predict the Pharmacokinetics of Irbesartan in Different CYP2C9 Genotypes
    Lee, Seok-Yong
    Cho, Chang-Keun
    Kang, Pureum
    Ko, Eunvin
    Mu, Chou Yen
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2023, 385
  • [43] Physiologically based pharmacokinetic (PBPK) modeling to predict the pharmacokinetics of irbesartan in different CYP2C9 genotypes
    Cho, Chang-Keun
    Kang, Pureum
    Jang, Choon-Gon
    Lee, Seok-Yong
    Lee, Yun Jeong
    Choi, Chang-Ik
    ARCHIVES OF PHARMACAL RESEARCH, 2023, 46 (11-12) : 939 - 953
  • [44] Physiologically based pharmacokinetic (PBPK) modeling to predict the pharmacokinetics of irbesartan in different CYP2C9 genotypes
    Chang-Keun Cho
    Pureum Kang
    Choon-Gon Jang
    Seok-Yong Lee
    Yun Jeong Lee
    Chang-Ik Choi
    Archives of Pharmacal Research, 2023, 46 : 939 - 953
  • [45] CYP2B6 and POR Polymorphisms Influence Metabolism and Clinical Outcomes of Perioperative Methadone in Children
    Packiasabapathy, Senthil
    Aruldhas, Blessed
    Zhang, Pengyue
    Sadhasivam, Senthilkumar
    ANESTHESIA AND ANALGESIA, 2021, 132 (5S_SUPPL): : 791 - 793
  • [46] The Influence of Sex, Ethnicity, and CYP2B6 Genotype on Bupropion Metabolism as an Index of Hepatic CYP2B6 Activity in Humans
    Ilic, Katarina
    Hawke, Roy L.
    Thirumaran, Ranjit K.
    Schuetz, Erin G.
    Hull, J. Heyward
    Kashuba, Angela D. M.
    Stewart, Paul W.
    Lindley, Celeste M.
    Chen, Mei-Ling
    DRUG METABOLISM AND DISPOSITION, 2013, 41 (03) : 575 - 581
  • [47] Allele and genotype frequencies of CYP2B6 in a Turkish population
    Yuce-Artun, Nazan
    Kose, Gulcin
    Suzen, H. Sinan
    MOLECULAR BIOLOGY REPORTS, 2014, 41 (06) : 3891 - 3896
  • [48] Stereoselective metabolism of methadone (M) by CYP2B6 and CYP2C19.
    Gerber, JG
    Rhodes, RJ
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2001, 69 (02) : P11 - P11
  • [49] PXR Polymorphisms Interacted With CYP2B6 Polymorphisms on Methadone Metabolites
    Tsai, Hui-Ju
    Wang, Sheng-Chang
    Tian, Jia-Ni
    Chang, Tsung-Kai
    Ho, Ing-Kang
    Hsiao, Chin-Fu
    Chen, Chia-Hui
    Tan, Happy Kuy-Lok
    Lin, Linen
    Wu, Chi-Shin
    Su, Lien-Wen
    Huang, Chieh-Liang
    Yang, Yi-Hong
    Liu, Ming-Lun
    Lin, Keh-Ming
    Liu, Yu-Li
    JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2013, 33 (01) : 137 - 140
  • [50] ROLE OF CYP2B6 POLYMORPHISM IN THE METABOLISM AND PHARMACOKINETICS OF METHADONE ENANTIOMERS
    Somogyi, A. A.
    Coller, J. K.
    Foster, D. B. F.
    Li, Y.
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2011, 109 : 32 - 32
12345