Porcine pancreatic lipase mediated regio- and stereoselective hydrolysis:: chemoenzymatic synthesis of (2S,3S)-2-amino-3,4-dihydroxybutyric acid

被引：8

作者：

Fadnavis, NW ^{[1
]}

Sharfuddin, M ^{[1
]}

Vadivel, SK ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Biotransformat Lab, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 05期

关键词：

D O I：

10.1016/S0957-4166(01)00099-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Porcine pancreatic lipase was used in the chemoenzymatic hydrolysis of 2-azido-3-hydroxy-3-methylcarbonyloxybutyl acetate The reaction occurred with high regio- and stereoselectivity to give enantiomerically pure (2S.3R)-3-azido-2-4-dihydroxy butyl acetate 5 (e.e. > 99%) which was easily converted to (2S,3S)-2-amno-3.4-dihydroxybutyric acid 1. an important synthetic intermediate in the synthesis of beta -lactam antibiotics and phytosiderophores, (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：691 / 693

页数：3

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