Porcine pancreatic lipase mediated regio- and stereoselective hydrolysis:: chemoenzymatic synthesis of (2S,3S)-2-amino-3,4-dihydroxybutyric acid

被引：8
|
作者：
Fadnavis, NW [1 ]
Sharfuddin, M [1 ]
Vadivel, SK [1 ]
机构：
[1] Indian Inst Chem Technol, Biotransformat Lab, Hyderabad 500007, Andhra Pradesh, India
来源：
TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 05期
关键词：
D O I：
10.1016/S0957-4166(01)00099-4
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Porcine pancreatic lipase was used in the chemoenzymatic hydrolysis of 2-azido-3-hydroxy-3-methylcarbonyloxybutyl acetate The reaction occurred with high regio- and stereoselectivity to give enantiomerically pure (2S.3R)-3-azido-2-4-dihydroxy butyl acetate 5 (e.e. > 99%) which was easily converted to (2S,3S)-2-amno-3.4-dihydroxybutyric acid 1. an important synthetic intermediate in the synthesis of beta -lactam antibiotics and phytosiderophores, (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：691 / 693
页数：3
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