B cells for cancer immunotherapy

被引：6

作者：

Deng, Jiusheng ^{[1
]}

Galipeau, Jacques ^{[1
,2
]}

机构：

[1] Emory Univ, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA

[2] Emory Univ, Dept Pediat, Winship Canc Inst, Atlanta, GA 30322 USA

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 10期

关键词：

B cells; cancer immunotherapy; fusion cytokine; GIFT4; ANTITUMOR IMMUNITY;

D O I：

10.4161/21624011.2014.955702

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have engineered a novel fusion cytokine named GIFT4 derived from GM-CSF and IL-4, and displaying robust gain-of-function immunostimulatory effects on B cells. GIFT4-programmed B cells have a unique identity and potent capacity to elicit a tumoricidal - cell response, thus comprising a novel B cell-based cancer immunotherapeutic approach.

引用

页码：e955702 / 1

页数：3

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