Infectious mononucleosis, immune genotypes, and non-Hodgkin lymphoma (NHL): an InterLymph Consortium study

被引:11
|
作者
Wade, Niquelle Brown [1 ,2 ]
Chang, Cindy M. [3 ]
Conti, David [1 ,4 ]
Millstein, Joshua [1 ,4 ]
Skibola, Christine [5 ,6 ]
Nieters, Alexandra [6 ]
Wang, Sophia S. [7 ]
De Sanjose, Silvia [8 ,9 ]
Kane, Eleanor [10 ]
Spinelli, John J. [11 ,12 ]
Bracci, Paige [12 ]
Zhang, Yawei [13 ,14 ]
Slager, Susan [15 ]
Wang, Jun [1 ,4 ]
Hjalgrim, Henrik [16 ,17 ]
Smedby, Karin Ekstrom [18 ]
Brown, Elizabeth E. [19 ]
Jarrett, Ruth F. [20 ]
Cozen, Wendy [1 ,4 ,21 ]
机构
[1] Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Ctr Genet Epidemiol, Los Angeles, CA 90033 USA
[2] Cigna Hlth & Life Insurance Co Cigna, Bloomfield, CT USA
[3] US FDA, Div Populat Hlth Sci, Ctr Tobacco Prod, Bethesda, MD 20014 USA
[4] Univ Southern Calif, Keck Sch Med, USC Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA
[5] Emory Univ, Sch Med, Dept Hematol & Med Oncol, Atlanta, GA USA
[6] Univ Freiburg, Univ Med Ctr Freiburg, CCI, Freiburg, Germany
[7] City Hope Comprehens Canc Ctr, Dept Computat & Quantitat Med, Duarte, CA USA
[8] Sexual & Reprod Hlth, PATH, Seattle, WA USA
[9] Univ York, Dept Hlth Sci, York YO10 5DD, N Yorkshire, England
[10] BC Canc Agcy, Populat Oncol, Vancouver, BC, Canada
[11] Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC, Canada
[12] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA
[13] Yale Sch Med, Dept Surg, New Haven, CT USA
[14] Yale Sch Publ Hlth, New Haven, CT USA
[15] Mayo Clin, Dept Epidemiol, Rochester, MN USA
[16] Statens Serum Inst, Dept Epidemiol Res, Copenhagen, Denmark
[17] Rigshospitalet, Dept Haematol, Copenhagen, Denmark
[18] Karolinska Univ, Sweden Univ Hosp, Karolinska Inst, Stockholm, Sweden
[19] Univ Alabama Birmingham, ONeal Comprehens Canc Ctr, Dept Pathol, Birmingham, AL USA
[20] MRC Univ Glasgow Ctr Virus Res, Glasgow, Lanark, Scotland
[21] Univ Southern Calif, Dept Pathol, Keck Sch Med, Los Angeles, CA 90033 USA
基金
美国国家卫生研究院;
关键词
Infectious mononucleosis; Non-Hodgkin lymphoma; T-cell lymphoma; Interleukin-1beta (IL1B); Interleukin-6 (IL6); Gene-environment interaction; EPSTEIN-BARR-VIRUS; T-CELL LYMPHOMAS; HLA CLASS-I; GENETIC-VARIATION; MEDICAL HISTORY; POOLED ANALYSIS; EPIDEMIOLOGIC RESEARCH; INFLAMMATION GENES; RISK; POLYMORPHISMS;
D O I
10.1007/s10552-020-01266-4
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose We explored the interaction between non-Hodgkin lymphoma (NHL), infectious mononucleosis (IM) history, and immune-related genotypes in a pooled case-control analysis. Methods A total of 7,926 NHL patients and 10,018 controls from 12 case-control studies were included. Studies were conducted during various time periods between 1988 and 2008, and participants were 17-96 years of age at the time of ascertainment/recruitment. Self-reported IM history and immune response genotypes were provided by the InterLymph Data Coordinating Center at Mayo Clinic. Odds ratios (OR) were estimated using multivariate logistic regression, and interactions were estimated using the empirical Bayes method. P-ACT was used to account for multiple comparisons. Results There was evidence of an interaction effect between IM history and two variants on T-cell lymphoma (TCL) risk: rs1143627 in interleukin-1B (IL1B) (p(interaction) = 0.04, ORinteraction = 0.09, 95% confidence interval [CI] 0.01, 0.87) and rs1800797 in interleukin-6 (IL6) (p(interaction) = 0.03, ORinteraction = 0.08, 95% CI 0.01, 0.80). Neither interaction effect withstood adjustment for multiple comparisons. There were no statistically significant interactions between immune response genotypes and IM on other NHL subtypes. Conclusions Genetic risk variants in IL1B and IL6 may affect the association between IM and TCL, possibly by influencing T-cell activation, growth, and differentiation in the presence of IM, thereby decreasing risk of immune cell proliferation.
引用
收藏
页码:451 / 462
页数:12
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