Rat carnitine palmitoyltransferase Iβ mRNA splicing isoforms

被引：12
|
作者：
Yu, GS
Lu, YC
Gulick, T
机构：
[1] Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02129 USA
[2] Massachusetts Gen Hosp, Med Serv, Boston, MA 02129 USA
[3] Harvard Univ, Sch Med, Dept Med, Boston, MA USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM | 1998年 / 1393卷 / 01期
关键词：
carnitine palmitoyltransferase; fatty acid oxidation; mRNA splicing; mitochondrion;
D O I：
10.1016/S0005-2760(98)00075-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Carnitine palmitoyltransferase I (CPT-I) catalyzes the rate-determining step in mitochondrial fatty acid beta-oxidation. The enzyme has two cognate structural genes (alpha and beta) that are differentially expressed in tissues. We show multiple mature mRNAs in rat heart derived from alternative splicing of CPT-I beta transcripts. Two novel messages are deleted for regions of the previously described mRNA that encode membrane-spanning and regulatory domains, suggesting that the cognate isozymes will exhibit unique kinetic characteristics. (C) 1998 Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码：166 / 172
页数：7
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