An expanded parenchymal CD8+ T cell clone in GABAA receptor encephalitis

被引：16

作者：

Bracher, Aline ^{[1
]}

Alcala, Carmen ^{[2
]}

Ferrer, Jaime ^{[3
]}

Melzer, Nico ^{[4
,5
]}

Hohlfeld, Reinhard ^{[1
,6
]}

Casanova, Bonaventura ^{[2
]}

Beltran, Eduardo ^{[1
]}

Dornmair, Klaus ^{[1
,6
]}

机构：

[1] Ludwig Maximilians Univ Munchen, Biomed Ctr & Hosp, Inst Clin Neuroimmunol, Munich, Germany

[2] Hosp Univ & Politecn La Fe, Dept Neurol, Valencia, Spain

[3] Hosp Univ & Politecn La Fe, Dept Pathol, Valencia, Spain

[4] Univ Hosp Munster, Clin Neurol, Munster, Germany

[5] Univ Hosp Munster, Inst Translat Neurol, Munster, Germany

[6] Munich Cluster Syst Neurol SyNergy, Munich, Germany

来源：

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | 2020年 / 7卷 / 02期

关键词：

RASMUSSEN ENCEPHALITIS; MULTIPLE-SCLEROSIS; AUTOANTIBODIES; ANTIBODIES; PERSIST; TUMOR;

D O I：

10.1002/acn3.50974

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The role of T cells in autoimmune encephalitis syndromes with autoantibodies against cell surface antigens is still enigmatic. Here we analyzed the T cell receptor repertoires of CD8+ and CD4+ T cells in a patient with "idiopathic" gamma-aminobutyric-acid-A receptor (GABA(A)-R) encephalitis by next-generation sequencing and single-cell analyses. We identified a CD8+ T cell clone that was strongly expanded in the cerebrospinal fluid and in the hippocampus but not in the operculo-insular cortex. By contrast, CD4+ T cells were polyclonal in these tissues. Such a strong clonal expansion suggests that CD8+ T cells may play a significant role in the pathogenesis.

引用

页码：239 / 244

页数：6

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