Effects of neuroactive substances on the morphine-induced respiratory depression; an in vitro study

被引：20
|
作者：
Takita, K
Herlenius, E
Yamamoto, Y
Lindahl, SGE
机构：
[1] Karolinska Hosp, Dept Woman & Child Hlth, S-17176 Stockholm, Sweden
[2] Karolinska Inst, S-17176 Stockholm, Sweden
[3] Hokkaido Univ, Sch Med, Dept Anesthesiol & Intens Care, Kita Ku, Sapporo, Hokkaido 060, Japan
[4] Karolinska Hosp, Dept Anesthesiol & Intens Care, S-17176 Stockholm, Sweden
来源：
BRAIN RESEARCH | 2000年 / 884卷 / 1-2期
关键词：
brainstem; respiration; opioid; acetylcholine; substance P; TRH;
D O I：
10.1016/S0006-8993(00)02921-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Effects of different neuroactive substances on morphine-induced respiratory depression were studied in medullary respiration-related structures using in vitro brainstem-spinal cord preparation from 1 to 4-day-old rats. Application of morphine (10 muM) reduced respiratory rhythm (fR) as measured by C4 ventral root activity. The depressant effects of morphine were reversed by acetylcholine (10 muM), substance P (50 nM), thyrotropin releasing hormone (TRH) (100 nM) and forskolin (10 muM). The adenosine receptor antagonist, theophylline (100 muM), the dopamine receptors antagonist, haloperidol (10 muM), the cyclooxygenase inhibitor, indomethacin (10 muM) and the phospholipase A, inhibitor, quinacrine (10 muM) had no effect on morphine-induced respiratory depression. (C) 2000 Elsevier Science BN. All rights reserved.
引用
收藏
页码：201 / 205
页数：5
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