Utility of animal gastrointestinal motility and transit models in functional gastrointestinal disorders

被引：10

作者：

Al-Saffar, Ahmad ^{[1
]}

Takemi, Shota ^{[2
]}

Saaed, Hiwa K. ^{[3
]}

Sakata, Ichiro ^{[2
]}

Sakai, Takafumi ^{[2
,4
]}

机构：

[1] Uppsala Univ Hosp, Dept Med Sci Gastroeneterol & Hepatol, S-75185 Uppsala, Sweden

[2] Saitama Univ, Grad Sch Sci & Engn, Div Life Sci, Area Regulatory Biol,Sakura Ku, 255 Shimo Ohkubo, Saitama 3388570, Japan

[3] Univ Sulaimani, Coll Pharm, Dept Pharmacol & Toxicol, Sulaymaniyah, Iraq

[4] Saitama Univ, Grad Sch Sci & Engn, Div Strategy Res, Area Life NanoBio,Sakura Ku, 255 Shimo Ohkubo, Saitama 3388570, Japan

来源：

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2019年 / 40-41卷

基金：

日本学术振兴会;

关键词：

Gastrointestinal motility; Functional gastrointestinal disorders; Animal model; ENTERIC NERVOUS-SYSTEM; GASTRIC-MOTILITY; INTESTINAL MOTILITY; INTERSTITIAL-CELLS; DRUG DISCOVERY; GI-DISORDERS; IN-VITRO; RECEPTORS; SEROTONIN; 5-HYDROXYTRYPTAMINE;

D O I：

10.1016/j.bpg.2019.101633

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Alteration in the gastrointestinal (GI) motility and transit comprises an important component of the functional gastrointestinal disorders (FGID). Available animal GI motility and transit models are to study symptoms (delayed gastric emptying, constipation, diarrhea) rather than biological markers to develop an effective treatment that targets the underlying mechanism of altered GI motility in patients. Animal data generated from commonly used methods in human like scintigraphy, breath test and wireless motility capsule may directly translate to the clinic. However, species differences in the control mechanism or pharmacological responses of GI motility may compromise the predictive and translational value of the preclinical data to human. In this review we aim to provide a summary on animal models used to mimic GI motility alteration in FGID, and the impact of the species differences in the physiological and pharmacological responses on the translation of animal GI motility and transit data to human. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页数：7

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