DNA Repair Mechanisms in Colorectal Carcinogenesis

被引：19

作者：

Michailidi, C. ^{[1
]}

Papavassiliou, A. G. ^{[1
]}

Troungos, C. ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Dept Biol Chem, GR-11527 Athens, Greece

来源：

CURRENT MOLECULAR MEDICINE | 2012年 / 12卷 / 03期

关键词：

Biomarker; colorectal carcinogenesis; DNA repair; gene polymorphism; genetic instability; genetic predisposition; NUCLEOTIDE EXCISION-REPAIR; DOUBLE-STRAND BREAKS; MLH1-93G-GREATER-THAN-A PROMOTER POLYMORPHISM; MUTY HOMOLOG HMYH; MISMATCH REPAIR; MICROSATELLITE-INSTABILITY; GENE POLYMORPHISMS; COLON-CANCER; ADJUVANT CHEMOTHERAPY; GERMLINE MUTATIONS;

D O I：

10.2174/156652412799218859

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Colon cancer is among the most common cancers and the third cause of cancer deaths worldwide. If detected at an early stage, treatment might often lead to cure. The present review adduces the so far studied alterations in the expression of genes, as well as polymorphisms of genes engaged in DNA repair systems, with particular emphasis on indirect ones that are correlated with colorectal cancer. Such aberrations could be linked to an increased risk for the development of colorectal cancer and might serve as potential targets in the areas of prevention and therapy.

引用

页码：237 / 246

页数：10

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