Studies on preparation of matrine solid dispersion sustained-release tablets

Objective: Matrine was made into solid dispersion sustained-release tablets. Methods: Ingredients are screened by single factor test and orthogonal, forming ingredient of sustained-release tablets was determined by appearance, formability, dissolution and d hardness of tablets. Results: The result showed that the optimum formulation was composed of HPMC 12g, lactose 9.5,3% PVP 8ml, magnesium stearate 0.5g. Conclusion: Matrine solid dispersion sustained-release tablets meets the requirement of meets the requirements of suspension preparation with pharmacopoeia with stable quality. Sophora flavescens which contains a variety of alkaloids is the dry roots of legumes, whose main component is matrine extracted with ethanol organic solvent. Preventing liver injury, anti-hepatic fibrosis, antitumor, cardiovascular are the main pharmacological effects of matrine. the traditional oral dosage form of matrine absorption effect is relatively poor. preparation of matrine solid dispersion sustained-release tablets can improve drug stability, increase the solubility and reduce the number of medication to a stable plasma concentration and treatment effect which avoid the phenomenon of peak and valley because of timing positioning drug release.. [1-5]