Synthesis of nodulisporic acid 2"-oxazoles and 2"-thiazoles

被引：14
|
作者：
Berger, R
Shoop, WL
Pivnichny, JV
Warmke, LM
Zakson-Aiken, M
Owens, KA
deMontigny, P
Schmatz, DM
Wyvratt, MJ
Fisher, MH
Meinke, PT
Colletti, SL [1 ]
机构：
[1] Merck & Co Inc, Merck Res Labs, Rahway, NJ 07065 USA
[2] Merial LLC, Analyt Res & Dev, N Brunswick, NJ 08902 USA
来源：
ORGANIC LETTERS | 2001年 / 3卷 / 23期
关键词：
D O I：
10.1021/ol016651x
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] The semisynthetic conversion of nodulisporic acid A(1) into a set of three heterocyclic side chain derivatives provided compounds, highlighted by 6, with an improved spectrum of ectoparasiticidal activity and pharmacokinetic profile relative to the natural product.
引用
收藏
页码：3715 / 3718
页数：4
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