Ferroptosis and Its Potential Role in the Nervous System Diseases

被引:49
|
作者
Zhou, Yiyang [1 ,2 ]
Lin, Wei [1 ,2 ]
Rao, Tian [1 ,2 ]
Zheng, Jinyu [3 ]
Zhang, Tianlei [1 ,2 ]
Zhang, Min [1 ,2 ]
Lin, Zhenlang [1 ,2 ]
机构
[1] Wenzhou Med Univ, Affiliated Hosp 2, Sch Med 2, Dept Pediat,Taizhou Women & Childrens Hosp, Wenzhou 325000, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325000, Zhejiang, Peoples R China
[3] Wenzhou Med Univ, Dept Clin Med, Wenzhou 325000, Zhejiang, Peoples R China
关键词
ferroptosis; iron; lipid peroxidation; molecular mechanism; neurodevelopment; neurological diseases; CELL-DEATH RECOMMENDATIONS; OXIDATIVE STRESS; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; TRAUMATIC BRAIN; IN-VITRO; IRON; METABOLISM; MECHANISMS; EXPRESSION;
D O I
10.2147/JIR.S351799
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Ferroptosis is a novel regulated cell death characterized by metabolic disorders and iron-dependent oxidative destruction of the lipid bilayer. It is primarily caused by the imbalance of oxidation and anti-oxidation in the body and is precisely regulated by numerous factors and pathways inside and outside the cell. Recent studies have indicated that ferroptosis plays a vital role in the pathophysiological process of multiple systems of the body including the nervous system. Ferroptosis may be closely linked to the occurrence and development of neurodegenerative diseases, strokes, and brain tumors. It may also be involved in the development, maturation, and aging of the nervous system. Therefore, this study aims to investigate ferroptosis's occurrence and regulatory mechanism and summarize its research progress in the pathogenesis and treatment of neurological diseases. This would allow for novel ideas for basic and clinical research of neurological diseases.
引用
收藏
页码:1555 / 1574
页数:20
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