Innate recognition of non-self nucleic acids

被引：26
|
作者：
Chi, Hongbo [3 ]
Flavell, Richard A. [1 ,2 ]
机构：
[1] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA
[2] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
[3] St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA
来源：
GENOME BIOLOGY | 2008年 / 9卷 / 03期
关键词：
D O I：
10.1186/gb-2008-9-3-211
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The immune system has evolved a plethora of innate receptors that detect microbial DNA and RNA, including Toll-like receptors in the endosomal compartment and RIG-I-like receptors and Nod-like receptors in the cytosol. Here we discuss the recognition of and responses to non-self nucleic acids via these receptors as well as their involvement in autoimmune diseases.
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