Contribution of aquaporins in the transamniotic water flux

被引：2

作者：

Di Paola, Mauricio ^{[1
,2
]}

Sierra, Matias N. ^{[1
]}

Fernandez, Nazarena ^{[1
]}

Ibarra, Cristina ^{[3
]}

Damiano, Alicia E. ^{[1
,2
]}

机构：

[1] Univ Buenos Aires, Fac Farm & Bioquim, Dept Ciencias Biol, Catedra Biol Celular & Mol, Junin 956 1er Piso, RA-1113 Buenos Aires, DF, Argentina

[2] Univ Buenos Aires, Fac Med, CONICET, Inst Fisiol & Biofis Bernardo Houssay IFIBIO,Lab, Buenos Aires, DF, Argentina

[3] Univ Buenos Aires, Fac Med, Dept Fisiol,Lab Fisiopatogenia, CONICET,Inst Fisiol & Biofis Bernardo Houssay IFI, Buenos Aires, DF, Argentina

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2022年 / 590卷

关键词：

AQPs; Amnion; Water transport; VOLUME; EXPRESSION; PLACENTA; SYSTEM;

D O I：

10.1016/j.bbrc.2021.12.097

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We explored the contribution of each aquaporin (AQP) expressed in human amnion in the transcellular water flux across the human amnion. Human amnion was placed between two lucite chambers and net water transport (Jw) was recorded by applying a hydrostatic (7 cm H2O) and an osmotic (40 mOsm PEG 8000) pressure gradients. The hydrostatic (Phydr) and osmotic (POsm) permeabilities were calculated before and after the blocking of AQPs. Phdr showed no significant difference after the blocking of AQPs, while POsm was dramatically reduced. Interestingly, we also found that the blocking of AQP1 produced the highest decrease of POsm (80 +/- 1%). Our results strongly suggested that AQP1 seems to contribute more to the maintenance of AF volume homeostasis. (C) 2021 Elsevier Inc. All rights reserved.

引用

页码：63 / 67

页数：5

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