A novel oestrogen-regulated gene in human breast cancer cells identified by differential display

被引：4
|
作者：
Stephen, R [1 ]
Corcoran, D [1 ]
Darbre, PD [1 ]
机构：
[1] Univ Reading, Sch Anim & Microbial Sci, Div Cell & Mol Biol, Reading RG6 6AJ, Berks, England
来源：
JOURNAL OF MOLECULAR ENDOCRINOLOGY | 1998年 / 20卷 / 03期
关键词：
D O I：
10.1677/jme.0.0200375
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Screening by differential display of oestrogen-sensitive MCF7 human breast cancer cells grown in the short-term (6 days) and long-term (70 weeks) absence of oestrogen has led to the identification of a new oestrogen-regulated mRNA. The cDNA isolated by differential display has 100% homology from nucleotides 615 to 859 of the published sequence for the mRNA for human megakaryocyte CD63 antigen but has a 3' tail extended by 23 nucleotides. Northern blotting has confirmed that this mRNA is regulated by oestrogen in both MCF7 and T47D human breast cancer cell lines.
引用
收藏
页码：375 / 380
页数：6
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