Dysfunctions, Molecular Mechanisms, and Therapeutic Strategies of Regulatory T Cells in Rheumatoid Arthritis

被引：9

作者：

Li, Xiaoya ^{[1
,2
]}

Xu, Huihui ^{[3
]}

Huang, Jing ^{[4
]}

Luo, Dan ^{[5
]}

Lv, Shuang ^{[2
]}

Lu, Xiangchen ^{[2
,4
]}

Xiao, Cheng ^{[2
,6
]}

机构：

[1] Chinese Acad Med Sci, Inst Med Plant Dev, Peking Union Med Coll, Beijing, Peoples R China

[2] China Japan Friendship Hosp, Inst Clin Med Sci, Beijing, Peoples R China

[3] China Acad Chinese Med Sci, Expt Res Ctr, Beijing Key Lab Res Chinese Med Prevent & Treatme, Beijing, Peoples R China

[4] Beijing Univ Chinese Med, Sch Tradit Chinese Med, Beijing, Peoples R China

[5] Tradit Chinese Med Hosp Changping Dist, Dept Ophthalmol, Beijing, Peoples R China

[6] China Japan Friendship Hosp, Dept Emergency, Beijing, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2021年 / 12卷

基金：

中国国家自然科学基金;

关键词：

rheumatoid arthritis; Tregs; molecular mechanisms; dysfunctions; therapeutic strategies; ARYL-HYDROCARBON RECEPTOR; COLLAGEN-INDUCED ARTHRITIS; GROWTH-FACTOR BETA-1; FOXP3(+) TREG CELLS; DISEASE-ACTIVITY; PERIPHERAL-BLOOD; DENDRITIC CELLS; TGF-BETA; SUPPRESSIVE FUNCTION; CUTTING EDGE;

D O I：

10.3389/fphar.2021.716081

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Regulatory T cells (Tregs) represent a distinct subpopulation of CD4(+) T lymphocytes that promote immune tolerance and maintain immune system homeostasis. The dysfunction of Tregs is tightly associated with rheumatoid arthritis (RA). Although the complex pathogenic processes of RA remain unclear, studies on Tregs in RA have achieved substantial progress not only in fundamental research but also in clinical application. This review discusses the current knowledge of the characterizations, functions, and molecular mechanisms of Tregs in the pathogenesis of RA, and potential therapies for these disorders are also involved.

引用

页数：16

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