Establishment of a novel animal model of ALS/FTD expressing G4C2 repeat RNA in Drosophila

被引:0
|
作者
Ueyama, Morio [1 ]
Ishiguro, Taro [1 ,2 ]
Fujikake, Nobuhiro [1 ]
Konno, Takuya [3 ]
Koyama, Akihide [3 ]
Onodera, Osamu [3 ]
Wada, Keiji [1 ]
Nagai, Yoshitaka [1 ]
机构
[1] Tokyo Med & Dent Univ, Natl Cent Neurol & Psychiat, Natl Inst Neurosci, Dept Degenerat Neurol Dis, Tokyo, Japan
[2] Tokyo Med & Dent Univ, Dept Neurol & Neurol Sci, Tokyo, Japan
[3] Niigata Univ, Brain Res Inst, Dept Neurol, Niigata 951, Japan
关键词
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
WS4-1
引用
收藏
页码:366 / 366
页数:1
相关论文
共 49 条
  • [21] Characterization of a Novel C9orf72 (G4C2)80 Knockin Rat Model
    Meurice, Claire
    Luo, Zhengyu
    Bodinizzo, Renee
    Chen, Yao
    Hill, Jaunetta
    He, Ye
    Bladon, John
    Paz, Juliana Laverde
    Zeier, Zane
    Levit, Mikhail
    Jackson, Robert
    Dodge, James
    Goulet, Martin
    Rodriguez, Steven
    Tomassy, Giulio
    Mueller, Christian
    MOLECULAR THERAPY, 2024, 32 (04) : 875 - 875
  • [22] eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS
    Lindsey D. Goodman
    Mercedes Prudencio
    Ananth R. Srinivasan
    Olivia M. Rifai
    Virginia M.-Y. Lee
    Leonard Petrucelli
    Nancy M. Bonini
    Acta Neuropathologica Communications, 7
  • [23] eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS
    Goodman, Lindsey D.
    Prudencio, Mercedes
    Srinivasan, Ananth R.
    Rifai, Olivia M.
    Lee, Virginia M. -Y.
    Petrucelli, Leonard
    Bonini, Nancy M.
    ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2019, 7 (1) : 62
  • [24] Senataxin helicase, the causal gene defect in ALS4, is a significant modifier of C9orf72 ALS G4C2 and arginine-containing dipeptide repeat toxicity
    Craig L. Bennett
    Somasish Dastidar
    Frederick J. Arnold
    Spencer U. McKinstry
    Cameron Stockford
    Brian D. Freibaum
    Bryce L. Sopher
    Meilin Wu
    Glen Seidner
    William Joiner
    J. Paul Taylor
    Ryan J. H. West
    Albert R. La Spada
    Acta Neuropathologica Communications, 11
  • [25] Stereopure Antisense Oligonucleotides Preferentially Knockdown G4C2 Repeat-Containing C9ORF72 Transcripts: A Potential Therapeutic Approach for the Treatment of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)
    Liu, Yuanjing
    Dodart, Jean-Cosme
    Tran, Helene
    Berkovitch, Shaunna
    Byrne, Michael
    Durbin, Ann
    Iwamoto, Naoki
    Jang, Hyun Gyung
    Kandasamy, Pachamuthu
    Mohapatra, Susovan
    Yang, Hailin
    Yin, Yuan
    Zhang, Jason
    Zhong, Zhong
    Vargeese, Chandra
    Brown, Robert
    NEUROLOGY, 2018, 90
  • [26] Senataxin helicase, the causal gene defect in ALS4, is a significant modifier of C9orf72 ALS G4C2 and arginine-containing dipeptide repeat toxicity
    Bennett, Craig L.
    Dastidar, Somasish
    Arnold, Frederick J.
    McKinstry, Spencer U.
    Stockford, Cameron
    Freibaum, Brian D.
    Sopher, Bryce L.
    Wu, Meilin
    Seidner, Glen
    Joiner, William
    Taylor, J. Paul
    West, Ryan J. H.
    La Spada, Albert R.
    ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2023, 11 (01)
  • [27] Crystal structure of a tetrameric RNA G-quadruplex formed by hexanucleotide repeat expansions of C9orf72 in ALS/FTD
    Geng, Yanyan
    Liu, Changdong
    Xu, Naining
    Suen, Monica Ching
    Miao, Haitao
    Xie, Yuanyuan
    Zhang, Bingchang
    Chen, Xueqin
    Song, Yuanjian
    Wang, Zhanxiang
    Cai, Qixu
    Zhu, Guang
    NUCLEIC ACIDS RESEARCH, 2024, 52 (13) : 7961 - 7970
  • [28] Somatic and intergenerational G4C2 hexanucleotide repeat instability in a human C9orf72 knock-in mouse model
    Kojak, Nada
    Kuno, Junko
    Fittipaldi, Kristina E.
    Khan, Ambereen
    Wenger, David
    Glasser, Michael
    Donnianni, Roberto A.
    Tang, Yajun
    Zhang, Jade
    Huling, Katie
    Ally, Roxanne
    Mujica, Alejandro O.
    Turner, Terrence
    Magardino, Gina
    Huang, Pei Yi
    Kerk, Sze Yen
    Droguett, Gustavo
    Prissette, Marine
    Rojas, Jose
    Gomez, Teodoro
    Gagliardi, Anthony
    Hunt, Charleen
    Rabinowitz, Jeremy S.
    Gong, Guochun
    Poueymirou, William
    Chiao, Eric
    Zambrowicz, Brian
    Siao, Chia-Jen
    Kajimura, Daisuke
    NUCLEIC ACIDS RESEARCH, 2024, 52 (10) : 5732 - 5755
  • [29] An ALS case with 38 (G4C2)-repeats in the C9orf72 gene shows TDP-43 and sparse dipeptide repeat protein pathology
    Dedeene, Lieselot
    Van Schoor, Evelien
    Race, Valerie
    Moisse, Matthieu
    Vandenberghe, Rik
    Poesen, Koen
    Van Damme, Philip
    Thal, Dietmar Rudolf
    ACTA NEUROPATHOLOGICA, 2019, 137 (05) : 855 - 858
  • [30] An ALS case with 38 (G4C2)-repeats in the C9orf72 gene shows TDP-43 and sparse dipeptide repeat protein pathology
    Lieselot Dedeene
    Evelien Van Schoor
    Valérie Race
    Matthieu Moisse
    Rik Vandenberghe
    Koen Poesen
    Philip Van Damme
    Dietmar Rudolf Thal
    Acta Neuropathologica, 2019, 137 : 855 - 858