The effect of orexin-A on the pathological mechanism in the rat focal cerebral ischemia

被引：51
|
作者：
Kitamura, Eiji [1 ]
Hamada, Junichi [1 ]
Kanazawa, Naomi [1 ]
Yonekura, Junko [1 ]
Masuda, Ray [1 ]
Sakai, Fumihiko
Mochizuki, Hideki [1 ]
机构：
[1] Kitasato Univ Sch Med, Dept Neurol, Minami Ku, Kanagawa 2520374, Japan
来源：
NEUROSCIENCE RESEARCH | 2010年 / 68卷 / 02期
关键词：
Orexin-A; Middle cerebral artery occlusion (MCAO); Brain ischemia; Neuroprotective effect; Rats; 2,3,5-Triphenyltetrazolium chloride (TTC); ARTERY OCCLUSION; RECEPTOR; NEURONS; ADULT;
D O I：
10.1016/j.neures.2010.06.010
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Orexin-A is a neuropeptide involved in the control feeding, arousal or sleep behavior in the hypothalamus. In the present study, the cortex and lateral hypothalamus of rats subjected to middle cerebral artery occlusion (MCAO)-reperfusion brain injury were examined by double immunofluorescence staining. The number of orexin-A-expressing neurons in the non-ischemic side was significantly lower than the ischemic side. Next, orexin-A was administered intracerebroventricularly followed by the induction of MCAO-reperfusion injury. Administration of orexin-A at 0.3 nmol significantly reduced the brain infarct area. The results suggested that orexin-A alters the pathological mechanisms involved in brain ischemia and has a neuroprotective effect. (C) 2010 Elsevier Ireland Ltd and the japan Neuroscience Society. All rights reserved.
引用
收藏
页码：154 / 157
页数：4
相关论文
共 50 条
  • [31] Electroacupuncture effect on synaptic ultrastructure in focal cerebral ischemia marginal zone of the rat
    Luo, Yan
    Xu, Nenggui
    Yi, Wei
    Yu, Tao
    Yang, Zhonghua
    NEURAL REGENERATION RESEARCH, 2010, 5 (08) : 618 - 622
  • [32] Protective effect of catalase overexpression in a model of rat transient focal cerebral ischemia
    Gu, WP
    JOURNAL OF NEUROSURGERY, 2004, 100 (01) : A193 - A194
  • [33] Protective effect of chlorogenic acid on the focal cerebral ischemia reperfusion rat models
    Miao, Mingsan
    Cao, Lihua
    Li, Ruiqi
    Fang, Xiaoyan
    Miao, Yanyan
    SAUDI PHARMACEUTICAL JOURNAL, 2017, 25 (04) : 556 - 563
  • [34] Neuroprotective effect of s-methylisothiourea in transient focal cerebral ischemia in rat
    ArunaDevi, Rathinam
    Ramteke, Vinod D.
    Kumar, Saurabh
    Shukla, Manoj K.
    Jaganathan, Subramani
    Kumar, Dinesh
    Sharma, Anil K.
    Tandan, Surendra K.
    NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2010, 22 (01): : 1 - 10
  • [35] The effect of orexin-A on motor and cognitive functions in a rat model of Parkinson's disease
    Hadadianpour, Zahra
    Fatehi, Farangis
    Ayoobi, Fateme
    Kaeidi, Ayat
    Shamsizadeh, Ali
    Fatemi, Iman
    NEUROLOGICAL RESEARCH, 2017, 39 (09) : 845 - 851
  • [36] Mitigation of Murine Focal Cerebral Ischemia by the Hypocretin/Orexin System is Associated With Reduced Inflammation
    Xiong, Xiaoxing
    White, Robin E.
    Xu, Lijun
    Yang, Liya
    Sun, Xiaoyun
    Zou, Bende
    Pascual, Conrado
    Sakurai, Takeshi
    Giffard, Rona G.
    Xie, Xinmin
    STROKE, 2013, 44 (03) : 764 - 770
  • [37] Analgesic effect of intrathecally administered orexin-A in the rat formalin test in the rat hot plate test
    Yamamoto, T
    Nozaki-Taguchi, N
    Chiba, T
    BRITISH JOURNAL OF PHARMACOLOGY, 2002, 137 (02) : 170 - 176
  • [38] Gait Impairment in a Rat Model of Focal Cerebral Ischemia
    Parkkinen, Saara
    Ortega, Francisco J.
    Kuptsova, Kristina
    Huttunen, Joanna
    Tarkka, Ina
    Jolkkonen, Jukka
    STROKE RESEARCH AND TREATMENT, 2013, 2013
  • [39] Axonal injury caused by focal cerebral ischemia in the rat
    Yam, PS
    Dewar, D
    McCulloch, J
    JOURNAL OF NEUROTRAUMA, 1998, 15 (06) : 441 - 450
  • [40] Sleep Disruption Aggravates Focal Cerebral Ischemia in the Rat
    Gao, Bo
    Cam, Ertugrul
    Jaeger, H.
    Zunzunegui, C.
    Sarnthein, Johannes
    Bassetti, Claudio L.
    SLEEP, 2010, 33 (07) : 879 - 887
12345